| ○種別 (必須): | □ | 総説·解説
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| ○言語 (必須): | □ | 日本語
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| ○招待 (推奨): | □ | 招待
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| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 福井 裕行
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| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Role of therapeutics for allergic diseases in targeting histamine H1 receptor gene expression (日) ヒスタミンH1受容体遺伝子発現機構を標的とするアレルギー疾患治療薬の意義
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| ○要約 (任意): | □ | (英) Histamine H(1) receptors are down-regulated as one step in receptor desensitization. Five phosphorylation sites of the H(1) receptor seem to play a key role in receptor down-regulation. In contrast, an increase in the H(1) receptor expression level following its mRNA elevation was found in the nasal mucosa in hypersensitivity model rats. Up-regulation of the H(1) receptor was induced by the direct stimulation of the H(1) receptor. H(1) receptor up-regulation was suppressed by pretreatment with antiallergic agents. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Anti-Allergic Agents (日) (読)
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| 3. | 細胞質分裂 (cytokinesis)
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| 4. | (英) Down-Regulation (日) (読)
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| 5. | (英) Drugs, Chinese Herbal (日) (読)
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| 6. | (英) Gene Expression Regulation (日) (読)
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| 7. | (英) Histidine Decarboxylase (日) (読)
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| 8. | (英) Humans (日) (読)
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| 9. | (英) Hypersensitivity (日) (読)
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| 10. | (英) Nasal Mucosa (日) (読)
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| 11. | (英) Phytotherapy (日) (読)
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| 12. | (英) RNA, Messenger (日) (読)
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| 13. | (英) Rats (日) (読)
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| 14. | (英) Receptors, Histamine H1 (日) (読)
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| 15. | (英) Up-Regulation (日) (読)
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| ○発行所 (推奨): | □ | 日本薬学会
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| ○誌名 (必須): | □ | 薬学雑誌 ([日本薬学会])
(pISSN: 0031-6903, eISSN: 1347-5231)
| ○ISSN (任意): | □ | 0031-6903
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| ○巻 (必須): | □ | 127
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 15 25
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2007年 0月 初日 (平成 19年 0月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1248/yakushi.127.15 (→Scopusで検索)
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| ○PMID (任意): | □ | 17202781 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Affiliation: Department of Molecular Pharmacology, Graduate School of Health Biosciences, The University of Tokushima, Tokushima City, Japan. hfukui@ph.tokushima-u.ac.jp (日)
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| 2. | (英) PublicationType: English Abstract (日)
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| 3. | (英) PublicationType: Journal Article (日)
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| 4. | (英) PublicationType: Review (日)
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