『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=212514EID:212514, Map:0, LastModified:2012年8月28日(火) 22:05:25, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[福井 裕行], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Shahriar Masum (日) (読)
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2.水口 博之
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3. (英) Maeyama Kazutaka (日) (読)
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4.北村 嘉章 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.耳鼻咽喉科学]/[徳島大学.病院.診療科.感覚·皮膚·運動機能科.耳鼻咽喉科・頭頸部外科])
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5. (英) Orimoto Naoki (日) (読)
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6.堀尾 修平
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7.梅原 隼人
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8. (英) Hattori Masashi (日) (読)
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9.武田 憲昭 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.耳鼻咽喉科学])
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10.福井 裕行
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題名 (必須): (英) Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine decarboxylase and IL-4 gene transcriptions.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Allergic rhinitis (AR) is an inflammatory disorder typified by symptoms such as sneezing, congestion, and rhinorrhea. Histamine plays important roles in eliciting AR symptoms. Up-regulation of the histamine H(1) receptor (H1R) and histidine decarboxylase (HDC) mRNAs was observed in AR patients. Th2 cytokines are also involved in the pathogenesis of AR. We examined the effect of suplatast tosilate on nasal symptoms, and H1R, HDC, and IL-4 gene expression using toluene-2,4-diisocyanate (TDI)-sensitized rats and HeLa cells expressing endogenous H1R. Provocation with TDI increased nasal symptoms, HDC activity, the histamine content of nasal lavage fluid, and the expression of H1R, HDC, and IL-4 mRNAs in TDI-sensitized rats. Pretreatment with suplatast for 2 wk significantly suppressed TDI-induced nasal symptoms and elevation of H1R, HDC, and IL-4 mRNAs. Suplatast also suppressed HDC activity in the nasal mucosa and the histamine content of the nasal lavage fluid. Bilateral injection of IL-4 into the nasal cavity of normal rats up-regulated H1R mRNA, while intranasal application of histamine up-regulated IL-4 mRNA. Suplatast suppressed IL-4-induced up-regulation of H1R mRNA in HeLa cells. However, it did not inhibit histamine-induced H1R mRNA elevation. These results suggest that suplatast alleviates nasal symptoms by inhibiting histamine signaling in TDI-sensitized rats through the suppression of histamine- and IL-4-induced H1R gene expression by the inhibitions of HDC and IL-4 gene transcriptions, respectively.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Arylsulfonates (日) (読) [継承]
3. (英) Down-Regulation (日) (読) [継承]
4. (英) Hela Cells (日) (読) [継承]
5. (英) Histamine (日) (読) [継承]
6. (英) Histidine Decarboxylase (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Interleukin-4 (日) (読) [継承]
9. (英) RNA, Messenger (日) (読) [継承]
10. (英) Rats (日) (読) [継承]
11. (英) Receptors, Histamine H1 (日) (読) [継承]
12.炎症性サイトカイン受容体の情報伝達 (Signal transduction of proinflammatory cytokine receptors) [継承]
13. (英) Sulfonium Compounds (日) (読) [継承]
14. (英) Toluene 2,4-Diisocyanate (日) (読) [継承]
15. (英) Transcription, Genetic (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 2133 2141 [継承]
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年月日 (必須): 西暦 2009年 7月 13日 (平成 21年 7月 13日) [継承]
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DOI (任意): 10.4049/jimmunol.0901058    (→Scopusで検索) [継承]
PMID (任意): 19596986    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Molecular Pharmacology, Institute of Health-Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Masum Shahriar, Hiroyuki Mizuguchi, Kazutaka Maeyama, Yoshiaki Kitamura, Naoki Orimoto, Shuhei Horio, Hayato Umehara, Masashi Hattori, Noriaki Takeda and Hiroyuki Fukui : Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine decarboxylase and IL-4 gene transcriptions., The Journal of Immunology, Vol.183, No.3, 2133-2141, 2009.
欧文冊子 ● Masum Shahriar, Hiroyuki Mizuguchi, Kazutaka Maeyama, Yoshiaki Kitamura, Naoki Orimoto, Shuhei Horio, Hayato Umehara, Masashi Hattori, Noriaki Takeda and Hiroyuki Fukui : Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine decarboxylase and IL-4 gene transcriptions., The Journal of Immunology, Vol.183, No.3, 2133-2141, 2009.

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