『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Lawson Mark A (日) (読)
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2. (英) Tsutsumi Rie (日) (読)
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3. (英) Zhang Hao (日) (読)
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4. (英) Talukdar Indrani (日) (読)
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[継承]
5. (英) Butler Brian K (日) (読)
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6. (英) Santos Sharon J (日) (読)
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7. (英) Mellon Pamela L (日) (読)
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8. (英) Webster Nicholas J G (日) (読)
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題名 (必須): (英) Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The hypothalamic-pituitary-gonadal endocrine axis regulates reproduction through estrous phase-dependent release of the heterodimeric gonadotropic glycoprotein hormones, LH and FSH, from the gonadotropes of the anterior pituitary. Gonadotropin synthesis and release is dependent upon pulsatile stimulation by the hypothalamic neuropeptide GnRH. Alterations in pulse frequency and amplitude alter the relative levels of gonadotropin synthesis and release. The mechanism of interpretation of GnRH pulse frequency and amplitude by gonadotropes is not understood. We have examined gene expression in LbetaT2 gonadotropes under various pulse regimes in a cell perifusion system by microarray and identified 1127 genes activated by tonic or pulsatile GnRH. Distinct patterns of expression are associated with each pulse frequency, but the greatest changes occur at a 60-min or less interpulse interval. The immediate early gene mRNAs encoding early growth response (Egr)1 and Egr2, which activate the gonadotropin LH beta-subunit gene promoter, are stably induced at high pulse frequency. In contrast, mRNAs for the Egr corepressor genes Ngfi-A binding protein Nab1 and Nab2 are stably induced at low pulse frequency. We show that Ngfi-A binding protein members inhibit Egr-mediated frequency-dependent induction of the LH beta-subunit promoter. This pattern of expression suggests a model of pulse frequency detection that acts by suppressing activation by Egr family members at low frequency and allowing activation at sustained high-frequency pulses.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cell Division (日) (読) [継承]
3. (英) Cells, Cultured (日) (読) [継承]
4. (英) Early Growth Response Protein 1 (日) (読) [継承]
5. (英) Feedback (日) (読) [継承]
6. (英) Gene Expression Profiling (日) (読) [継承]
7. (英) Gene Expression Regulation (日) (読) [継承]
8. (英) Kinetics (日) (読) [継承]
9. (英) L Cells (Cell Line) (日) (読) [継承]
10. (英) Luteinizing Hormone, beta Subunit (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Promoter Regions, Genetic (日) (読) [継承]
13. (英) RNA (日) (読) [継承]
14. (英) Repressor Proteins (日) (読) [継承]
15. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
16. (英) Transfection (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Molecular Endocrinology ([The Endocrine Society])
(pISSN: 0888-8809, eISSN: 1944-9917)

ISSN (任意): 0888-8809
ISSN: 0888-8809 (pISSN: 0888-8809, eISSN: 1944-9917)
Title: Molecular endocrinology (Baltimore, Md.)
Title(ISO): Mol Endocrinol
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1175 1191 [継承]
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年月日 (必須): 西暦 2007年 2月 13日 (平成 19年 2月 13日) [継承]
URL (任意):
DOI (任意): 10.1210/me.2006-0392    (→Scopusで検索) [継承]
PMID (任意): 17299135    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Reproductive Medicine 0674, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0674, USA. mlawson@ucsd.edu  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]

標準的な表示

和文冊子 ● A Mark Lawson, Rie Tsutsumi, Hao Zhang, Indrani Talukdar, K Brian Butler, J Sharon Santos, L Pamela Mellon and G Nicholas J Webster : Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2., Molecular Endocrinology, Vol.21, No.5, 1175-1191, 2007.
欧文冊子 ● A Mark Lawson, Rie Tsutsumi, Hao Zhang, Indrani Talukdar, K Brian Butler, J Sharon Santos, L Pamela Mellon and G Nicholas J Webster : Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2., Molecular Endocrinology, Vol.21, No.5, 1175-1191, 2007.

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