| ○種別 (必須): |
| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Erdenebayar Namjil (日) (読)
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| 2. | 前川 洋一
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| 3. | 西田 純
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| 4. | 北村 明子
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| 5. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| ○題名 (必須): | □ | (英) Protein-tyrosine phosphatase-kappa regulates CD4+ T cell development through ERK1/2-mediated signaling. (日)
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| ○要約 (任意): | □ | (英) T cells express diverse antigen-specific receptors and are required for eradicating pathogens and transformed cells. T cells expressing CD4 acquire helper effector functions and those expressing CD8 exert cytotoxic activity after antigen recognition. The protein-tyrosine phosphatase, receptor type kappa (PTPRKappa) is mutated in LEC rats, resulting in impaired CD4(+) T cell development in the thymus. However, the molecular mechanism of PTPRK controlling CD4(+) T cell development remains unclear. We demonstrate herein that inhibition of PTPRK by transducing a dominant negative form of the intracellular domain of PTPRK (PTPRK-ICD-DN) in bone marrow-derived stem cells suppresses the development of CD4(+) T cells. The inhibition of PTPRK by PTPRK-ICD-DN or short-hairpin RNA for PTPRK attenuates ERK1/2 phosphorylation in T cells after PMA and ionomycin stimulation. Total thymocytes from LEC rats also showed weaker phosphorylation of ERK1/2 after PMA and ionomycin stimulation than control thymocytes. Furthermore, inhibition of PTPRK by PTPRK-ICD-DN suppressed MEK1/2 and c-Raf phosphorylation, which is required for ERK1/2 phosphorylation. These data indicate that PPTRK positively regulates ERK1/2 phosphorylation, which impacts CD4(+) T cell development. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) CD4-Positive T-Lymphocytes (日) (読)
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| 3. | (英) Humans (日) (読)
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| 4. | (英) Jurkat Cells (日) (読)
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| 5. | (英) MAP Kinase Kinase 1 (日) (読)
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| 6. | (英) MAP Kinase Kinase 2 (日) (読)
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| 7. | (英) Mice (日) (読)
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| 8. | (英) Mitogen-Activated Protein Kinase 1 (日) (読)
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| 9. | (英) Mitogen-Activated Protein Kinase 3 (日) (読)
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| 10. | リン酸化 (phosphorylation)
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| 11. | (英) Rats (日) (読)
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| 12. | (英) Receptor-Like Protein Tyrosine Phosphatases, Class 2 (日) (読)
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| 13. | シグナル伝達 (signal transduction)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)
| ○ISSN (任意): | □ | 1090-2104
ISSN: 0006-291X
(pISSN: 0006-291X, eISSN: 1090-2104) Title: Biochemical and biophysical research communicationsTitle(ISO): Biochem Biophys Res CommunPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 390
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 489 493
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2009年 10月 1日 (平成 21年 10月 1日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bbrc.2009.09.117 (→Scopusで検索)
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| ○PMID (任意): | □ | 19800317 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-70449701442
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Immunology and Parasitology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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