『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=211507EID:211507, Map:0, LastModified:2013年8月21日(水) 16:10:24, Operator:[勢井 宏義], Avail:TRUE, Censor:0, Owner:[勢井 宏義], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Yamamoto Yuta (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Tanahashi Toshihito (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Kawai Tomoko (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Chikahisa Sachiko (日) (読)
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学籍番号 (推奨):
[継承]
5.勝浦 桜子 ([予防医学])
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[継承]
6. (英) Nishida Kensei (日) (読)
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[継承]
7. (英) Teshima-Kondo Shigetada (日) (読)
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[継承]
8.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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9. (英) Rokutan Kazuhito (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Changes in behavior and gene expression induced by caloric restriction in C57BL/6 mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Caloric restriction (CR) is an effective method for prevention of age-associated diseases as well as overweight and obesity; however, there is controversy regarding the effects of dieting regimens on behavior. In this study, we investigated two different dieting regimens: repeated fasting and refeeding (RFR) and daily feeding of half the amount of food consumed by RFR mice (CR). CR and RFR mice had an approximate 20% reduction in food intake compared with control mice. Open field, light-dark transition, elevated plus maze, and forced swimming tests indicated that CR, but not RFR, reduced anxiety- and depressive-like behaviors, with a reduction peak on day 8. Using a mouse whole genome microarray, we analyzed gene expression in the prefrontal cortex, amygdala, and hypothalamus. In addition to the CR-responsive genes commonly modified by RFR and CR, each regimen differentially changed the expression of distinct genes in each region. The most profound change was observed in the amygdalas of CR mice: 884 genes were specifically upregulated. Ingenuity pathway analysis revealed that these 884 genes significantly modified nine canonical pathways in the amygdala. alpha-Adrenergic and dopamine receptor signalings were the two top-scoring pathways. Quantitative RT-PCR confirmed the upregulation of six genes in these pathways. Western blotting confirmed that CR specifically increased dopamine- and cAMP-regulated phosphoprotein (Darpp-32), a key regulator of dopamine receptor signaling, in the amygdala. Our results suggest that CR may change behavior through altered gene expression.  (日)    [継承]
キーワード (推奨): 1. (英) Amygdala (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Behavior, Animal (日) (読) [継承]
4. (英) Blotting, Western (日) (読) [継承]
5. (英) Body Weight (日) (読) [継承]
6. (英) Caloric Restriction (日) (読) [継承]
7. (英) Dopamine and cAMP-Regulated Phosphoprotein 32 (日) (読) [継承]
8. (英) Eating (日) (読) [継承]
9. (英) Gene Expression Profiling (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Maze Learning (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Mice, Inbred C57BL (日) (読) [継承]
14. (英) Motor Activity (日) (読) [継承]
15. (英) Oligonucleotide Array Sequence Analysis (日) (読) [継承]
16. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
17. (英) Signal Transduction (日) (読) [継承]
18. (英) Swimming (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Physiological Genomics ([アメリカ生理学会])
(pISSN: 1094-8341, eISSN: 1531-2267)

ISSN (任意): 1531-2267
ISSN: 1094-8341 (pISSN: 1094-8341, eISSN: 1531-2267)
Title: Physiological genomics
Title(ISO): Physiol. Genomics
Publisher: American Physiological Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 227 235 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 9月 8日 (平成 21年 9月 8日) [継承]
URL (任意):
DOI (任意): 10.1152/physiolgenomics.00082.2009    (→Scopusで検索) [継承]
PMID (任意): 19737990    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yuta Yamamoto, Toshihito Tanahashi, Tomoko Kawai, Sachiko Chikahisa, Sakurako Katsuura, Kensei Nishida, Shigetada Teshima-Kondo, Hiroyoshi Sei and Kazuhito Rokutan : Changes in behavior and gene expression induced by caloric restriction in C57BL/6 mice., Physiological Genomics, Vol.39, No.3, 227-235, 2009.
欧文冊子 ● Yuta Yamamoto, Toshihito Tanahashi, Tomoko Kawai, Sachiko Chikahisa, Sakurako Katsuura, Kensei Nishida, Shigetada Teshima-Kondo, Hiroyoshi Sei and Kazuhito Rokutan : Changes in behavior and gene expression induced by caloric restriction in C57BL/6 mice., Physiological Genomics, Vol.39, No.3, 227-235, 2009.

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