『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=211492EID:211492, Map:0, LastModified:2015年11月15日(日) 17:02:46, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[松久 宗英], Read:継承, Write:継承, Delete:継承.
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言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Saitou Miyoko (日) (読)
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2. (英) Osonoi Takeshi (日) (読)
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3. (英) Kawamori Ryuzo (日) (読)
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4. (英) Katakami Naoto (日) (読)
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5. (英) Kaneto Hideaki (日) (読)
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6.松久 宗英 ([徳島大学.先端酵素学研究所.基幹研究部門]/徳島大学病院アンチエイジングセンター センター長(併任))
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7. (英) Yamasaki Yoshimistu (日) (読)
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題名 (必須): (英) Genetic risk factors and the anti-atherosclerotic effect of pioglitazone on carotid atherosclerosis of subjects with type 2 diabetes--a retrospective study.  (日)    [継承]
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要約 (任意): (英) AIM: Pioglitazone, an agonist of peroxisome proliferator-activated receptor gamma, showed various anti-atherosclerotic effects on type 2 diabetic patients. This retrospective study was done to ascertain which risk factor(s) associate with anti-atherosclerotic effects of pioglitazone. METHODS: We enrolled 160 diabetic patients treated through diet only and 62 treated with pioglitazone and annually evaluated carotid maximum (MaxIMT) and averaged intima-media thickness (AveIMT) for 2 years. We analyzed the relation of 99 single-nucleotide polymorphisms (SNP) as well as conventional risk factors with the progression or regression of carotid atherosclerosis. RESULTS: The D allele of the angiotensin-converting enzyme (ACE) gene and 677 allele of the methylene-tetrahydrofolate reductase (MTHFR) gene showed a significant association with increases in MaxIMT among the diabetic subjects treated through diet only. The pioglitazone-treated carriers of the D allele showed an attenuation of MaxIMT as compared with the diet-treated carriers. The pioglitazone-treated carriers of the 677T allele carriers showed a significant attenuation of MaxIMT compared with the diet-treated carriers. CONCLUSIONS: Pioglitazone may exert anti-atherosclerotic effects on type 2 diabetics carrying the ACE gene's D allele and/or MTHFR gene's 677T allele, who showed a progression of carotid atherosclerosis without the drug.  (日)    [継承]
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誌名 (必須): Journal of Atherosclerosis and Thrombosis (日本動脈硬化学会)
(pISSN: 1340-3478, eISSN: 1880-3873)

ISSN (任意): 1880-3873
ISSN: 1340-3478 (pISSN: 1340-3478, eISSN: 1880-3873)
Title: Journal of atherosclerosis and thrombosis
Title(ISO): J Atheroscler Thromb
Supplier: 一般社団法人 日本動脈硬化学会
Publisher: Japan Atherosclerosis Society
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 386 394 [継承]
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年月日 (必須): 西暦 2010年 4月 5日 (平成 22年 4月 5日) [継承]
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DOI (任意): 10.5551/jat.2527    (→Scopusで検索) [継承]
PMID (任意): 20134102    (→Scopusで検索) [継承]
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WOS (任意): 000278406000009 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Naka Kinen Clinics, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

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和文冊子 ● (種別) : Miyoko Saitou, Takeshi Osonoi, Ryuzo Kawamori, Naoto Katakami, Hideaki Kaneto, Munehide Matsuhisa and Yoshimistu Yamasaki : Genetic risk factors and the anti-atherosclerotic effect of pioglitazone on carotid atherosclerosis of subjects with type 2 diabetes--a retrospective study., Journal of Atherosclerosis and Thrombosis, Vol.17, No.4, 386-394, (発行所), (都市), April 2010.
欧文冊子 ● (種別) : Miyoko Saitou, Takeshi Osonoi, Ryuzo Kawamori, Naoto Katakami, Hideaki Kaneto, Munehide Matsuhisa and Yoshimistu Yamasaki : Genetic risk factors and the anti-atherosclerotic effect of pioglitazone on carotid atherosclerosis of subjects with type 2 diabetes--a retrospective study., Journal of Atherosclerosis and Thrombosis, Vol.17, No.4, 386-394, (発行所), (都市), April 2010.

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