| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Terauchi Satsuki (日) (読)
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| 2. | 山本 武範
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| 3. | 山下 菊治
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| 4. | 片岡 正俊
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| ○貢献度 (任意): |
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| 5. | 寺田 弘 ([東京理科大学])
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| 6. | 篠原 康雄 ([徳島大学.先端酵素学研究所.基幹研究部門])
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| ○題名 (必須): | □ | (英) Molecular basis of morphological changes in mitochondrial membrane accompanying induction of permeability transition, as revealed by immuno-electron microscopy. (日)
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| ○要約 (任意): | □ | (英) The mitochondrial inner membrane typically shows a condensed structure when examined by electron microscopy. However, this typical structure is known to disappear upon induction of the mitochondrial permeability transition (PT). This change in the appearance of the mitochondrial membrane structure that accompanies the induction of PT is thought to reflect changes in the permeability of inner mitochondrial membrane; however, its molecular basis has remained uncertain. In the present study, changes in membrane status were examined by immuno-electron microscopy using antibodies against the voltage-dependent anion channel (VDAC), beta-subunit of F1-ATPase (F1beta), and cytochrome c (cyt. c). In control mitochondria, antibody against VDAC was observed at the rim of the mitochondria, whereas antibodies against F1beta and cytochrome c bound these molecules inside of the mitochondria. However, in PT-induced mitochondria, all three antibodies were observed at the mitochondrial rim. These results strongly suggest that the inner mitochondrial membrane is shoved to the rim region of mitochondria upon induction of mitochondrial PT. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antibody Specificity (日) (読)
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| 3. | (英) Cytochromes c (日) (読)
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| 4. | (英) Intracellular Membranes (日) (読)
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| 5. | (英) Male (日) (読)
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| 6. | (英) Microscopy, Immunoelectron (日) (読)
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| 7. | (英) Mitochondria, Liver (日) (読)
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| 8. | (英) Permeability (日) (読)
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| 9. | (英) Porins (日) (読)
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| 10. | (英) Proton-Translocating ATPases (日) (読)
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| 11. | (英) Rabbits (日) (読)
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| 12. | (英) Rats (日) (読)
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| 13. | (英) Rats, Wistar (日) (読)
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| 14. | (英) Voltage-Dependent Anion Channels (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Mitochondrion (Mitochondria Research Society)
(pISSN: 1567-7249, eISSN: 1872-8278)
| ○ISSN (任意): | □ | 1567-7249
ISSN: 1567-7249
(pISSN: 1567-7249, eISSN: 1872-8278) Title: MitochondrionTitle(ISO): MitochondrionPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 5
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 248 254
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2005年 8月 初日 (平成 17年 8月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.mito.2005.04.002 (→Scopusで検索)
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| ○PMID (任意): | □ | 16050987 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Institute for Genome Research, University of Tokushima, Kuramotocho-3, Tokushima 770-8503, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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