『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須):
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Tsubota Kazuo (日) (読)
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[継承]
2. (英) Nishiyama Tatsuaki (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Mishima Kenji (日) (読)
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[継承]
4. (英) Inoue Hiroko (日) (読)
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[継承]
5. (英) Doi Takeshi (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Hattori Yukio (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Kodama Tatsuhiko (日) (読)
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[継承]
8. (英) Higuchi Akihiro (日) (読)
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[継承]
9.林 良夫
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[継承]
10. (英) Saito Ichiro (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) The role of fractalkine as an accelerating factor on the autoimmune exocrinopathy in mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) PURPOSE: Sjögren's syndrome (SS) is an organ-specific autoimmune disease caused by the progressive loss of exocrine glands and is associated with several autoimmune phenomena. Various research studies have been performed, and many molecules have been suggested as responsible for the pathogenesis of SS. Here the authors show the increased expression of fractalkine (CX(3)CL1) in lacrimal glands of SS model mice. Among more than 50 known chemokines, fractalkine is the sole member of the CX(3)C family and has unique structural and functional attributes. The purpose of this study was to analyze the role of fractalkine in exocrine glands. METHODS: The expression of fractalkine in the lacrimal glands of thymectomized NFS/sld mice was investigated by immunohistochemistry and RT-PCR. To confirm the effects of fractalkine in exocrine glands, tissue-specific fractalkine transgenic mice were generated using the salivary amylase promoter. RESULTS: The results demonstrated the upregulated fractalkine expression in thymectomized NFS/sld mice. Furthermore, the lacrimal and salivary gland-specific fractalkine transgenic mice showed the expression of fragmented fractalkine and lymphocytic infiltration in their lacrimal and submandibular glands. Interestingly, the dominant population was B cells in the lacrimal glands, whereas B cells and CD4(+) T cells were infiltrated in the submandibular glands. These mice also demonstrated slightly decreased tear and salivary secretion compared with wild-type mice. CONCLUSIONS: Based on these results, it may be that fractalkine contributes to the development of SS, especially in lymphocyte migration to exocrine glands, and that it accelerates the disease in association with other molecules.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Autoimmune Diseases (日) (読) [継承]
3. (英) CD4-Positive T-Lymphocytes (日) (読) [継承]
4. (英) CD8-Positive T-Lymphocytes (日) (読) [継承]
5. (英) Cell Movement (日) (読) [継承]
6. (英) Chemokine CX3CL1 (日) (読) [継承]
7. (英) Female (日) (読) [継承]
8. (英) Immunoblotting (日) (読) [継承]
9. (英) Immunohistochemistry (日) (読) [継承]
10. (英) Lacrimal Apparatus (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Mice, Inbred C57BL (日) (読) [継承]
13. (英) Mice, Transgenic (日) (読) [継承]
14. (英) RNA, Messenger (日) (読) [継承]
15. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
16. (英) Salivary Glands (日) (読) [継承]
17. (英) Sjogren's Syndrome (日) (読) [継承]
18. (英) Tears (日) (読) [継承]
19. (英) Thymectomy (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Investigative Ophthalmology & Visual Science (Association for Research in Vision and Ophthalmology)
(pISSN: 0146-0404, eISSN: 1552-5783)

ISSN (任意): 1552-5783
ISSN: 0146-0404 (pISSN: 0146-0404, eISSN: 1552-5783)
Title: Investigative ophthalmology & visual science
Title(ISO): Invest. Ophthalmol. Vis. Sci.
Publisher: Association for Research in Vision and Ophthalmology
 (NLM Catalog  (CrossRef  (CrossRef (Scopus information is found. [need login])
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(必須): 50 [継承]
(必須): 10 [継承]
(必須): 4753 4760 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 4月 30日 (平成 21年 4月 30日) [継承]
URL (任意):
DOI (任意): 10.1167/iovs.08-2596    (→Scopusで検索) [継承]
PMID (任意): 19407023    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Kazuo Tsubota, Tatsuaki Nishiyama, Kenji Mishima, Hiroko Inoue, Takeshi Doi, Yukio Hattori, Tatsuhiko Kodama, Akihiro Higuchi, Yoshio Hayashi and Ichiro Saito : The role of fractalkine as an accelerating factor on the autoimmune exocrinopathy in mice., Investigative Ophthalmology & Visual Science, Vol.50, No.10, 4753-4760, (発行所), (都市), April 2009.
欧文冊子 ● (種別) : Kazuo Tsubota, Tatsuaki Nishiyama, Kenji Mishima, Hiroko Inoue, Takeshi Doi, Yukio Hattori, Tatsuhiko Kodama, Akihiro Higuchi, Yoshio Hayashi and Ichiro Saito : The role of fractalkine as an accelerating factor on the autoimmune exocrinopathy in mice., Investigative Ophthalmology & Visual Science, Vol.50, No.10, 4753-4760, (発行所), (都市), April 2009.

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