『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kasagi Shimpei (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kawano Seiji (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3.岡崎 拓
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Honjo Tasuku (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Morinobu Akio (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Hatachi Saori (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Shimatani Kenichiro (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Tanaka Yoshimasa (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Minato Nagahiro (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
10. (英) Kumagai Shunichi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Programmed cell death 1 (PD-1) is an immunosuppressive receptor that transduces an inhibitory signal into activated T cells. Although a single nucleotide polymorphism in the gene for PD-1 is associated with susceptibility to systemic lupus erythematosus, the role of PD-1 in systemic lupus erythematosus is still not well understood. In this study, we used NZB/W F1 mice, a model of lupus-like nephritis, to examine the function of PD-1 and its ligands. PD-1 was predominantly expressed on CD4(+) T cells that infiltrated the kidney, and CD4(+)PD-1(high) T cells produced higher levels of IFN-gamma than CD4(+)PD-1(low) or CD4(+)PD-1(-) T cells. Stimulation with PMA/ionomycin caused splenic CD4(+)PD-1(+) T cells to secrete high levels of IFN-gamma, IL-10, low levels of TNF-alpha, faint levels of IL-2, IL-21, and no IL-4, IL-17. In vivo anti-PD-1 mAb treatment reduced the number of CD4(+)PD-1(+) T cells in the kidney of NZB/W F1 mice and significantly reduced their mortality rate (p = 0.03). Conversely, blocking PD-L1 using an anti-PD-L1 mAb increased the number of CD4(+)PD-1(+) T cells in the kidney, enhanced serum IFN-gamma, IL-10, and IgG2a ds-DNA-Ab levels, accelerated the nephritis, and increased the mortality rate. We conclude that CD4(+)PD-1(high) T cells are dysregulated IFN-gamma-producing, proinflammatory cells in NZB/W F1 mice.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antibodies, Antinuclear (日) (読) [継承]
3. (英) Antibodies, Monoclonal (日) (読) [継承]
4. (英) Antigens, CD80 (日) (読) [継承]
5. (英) Antigens, Differentiation (日) (読) [継承]
6. (英) CD4-Positive T-Lymphocytes (日) (読) [継承]
7. (英) Cell Proliferation (日) (読) [継承]
8. (英) Enzyme-Linked Immunosorbent Assay (日) (読) [継承]
9. (英) Female (日) (読) [継承]
10. (英) Flow Cytometry (日) (読) [継承]
11. (英) Interferon-gamma (日) (読) [継承]
12. (英) Kidney (日) (読) [継承]
13. (英) Male (日) (読) [継承]
14. (英) Membrane Glycoproteins (日) (読) [継承]
15. (英) Mice (日) (読) [継承]
16. (英) Nephritis (日) (読) [継承]
17. (英) Peptides (日) (読) [継承]
18. (英) Spleen (日) (読) [継承]
19. (英) Survival Rate (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 184 [継承]
(必須): 5 [継承]
(必須): 2337 2347 [継承]
都市 (任意):
年月日 (必須): 西暦 2010年 2月 5日 (平成 22年 2月 5日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.0901652    (→Scopusで検索) [継承]
PMID (任意): 20139271    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shimpei Kasagi, Seiji Kawano, Taku Okazaki, Tasuku Honjo, Akio Morinobu, Saori Hatachi, Kenichiro Shimatani, Yoshimasa Tanaka, Nagahiro Minato and Shunichi Kumagai : Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice., The Journal of Immunology, Vol.184, No.5, 2337-2347, 2010.
欧文冊子 ● Shimpei Kasagi, Seiji Kawano, Taku Okazaki, Tasuku Honjo, Akio Morinobu, Saori Hatachi, Kenichiro Shimatani, Yoshimasa Tanaka, Nagahiro Minato and Shunichi Kumagai : Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice., The Journal of Immunology, Vol.184, No.5, 2337-2347, 2010.

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