『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Chikuma Shunsuke (日) (読)
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[継承]
2. (英) Terawaki Seigo (日) (読)
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[継承]
3. (英) Hayashi Tamon (日) (読)
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[継承]
4. (英) Nabeshima Ryusuke (日) (読)
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[継承]
5. (英) Yoshida Takao (日) (読)
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6. (英) Shibayama Shiro (日) (読)
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7.岡崎 拓
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[継承]
8. (英) Honjo Tasuku (日) (読)
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[継承]
題名 (必須): (英) PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Accumulating evidence suggests that PD-1, an immuno-inhibitory receptor expressed on activated T cells, regulates peripheral T cell tolerance. In particular, PD-1 is involved in the induction and/or maintenance of T cells' intrinsic unresponsiveness to previously encountered Ags, although the mechanism is yet to be determined. We used a simple experimental model to dissect the mechanism for anergy establishment, in which 2C TCR transgenic rag2(-/-) PD-1(+/+) mice were anergized by a single injection of a cognate peptide. Interestingly, 2C rag2(-/-) PD-1(-/-) mice were totally resistant to anergy induction by the same treatment; thus, PD-1 was responsible for anergy induction. Furthermore, PD-1 expression was induced within 24 h of the initial Ag exposure. The establishment of anergy was associated with a marked down-regulation of IL-2 from the CD8(+) T cells. In fact, IL-2 blockade resulted in anergy even in 2C rag2(-/-)PD-1(-/-) T cells. Furthermore, the complementation of the IL-2 signal in 2C rag2(-/-) PD-1(+/+) mice reversed the anergy induction. We propose that CD8(+) T cell anergy is induced by a reduction of cell-autonomous IL-2 synthesis, which is caused by the quick expression of PD-1 in response to Ag stimulation and the subsequent stimulation of this receptor by its ligands on surrounding cells.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens (日) (読) [継承]
3. (英) Antigens, Differentiation (日) (読) [継承]
4. (英) CD8-Positive T-Lymphocytes (日) (読) [継承]
5. (英) Clonal Anergy (日) (読) [継承]
6. (英) Gene Expression Regulation (日) (読) [継承]
7. (英) Interleukin-2 (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9.ノックアウトマウス (knockout mice) [継承]
10. (英) Mice, Transgenic (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 182 [継承]
(必須): 11 [継承]
(必須): 6682 6689 [継承]
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年月日 (必須): 西暦 2009年 6月 初日 (平成 21年 6月 初日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.0900080    (→Scopusで検索) [継承]
PMID (任意): 19454662    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Immunology and Genetic Medicine, Graduate school of Medicine, Kyoto University, Kyoto, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shunsuke Chikuma, Seigo Terawaki, Tamon Hayashi, Ryusuke Nabeshima, Takao Yoshida, Shiro Shibayama, Taku Okazaki and Tasuku Honjo : PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo., The Journal of Immunology, Vol.182, No.11, 6682-6689, 2009.
欧文冊子 ● Shunsuke Chikuma, Seigo Terawaki, Tamon Hayashi, Ryusuke Nabeshima, Takao Yoshida, Shiro Shibayama, Taku Okazaki and Tasuku Honjo : PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo., The Journal of Immunology, Vol.182, No.11, 6682-6689, 2009.

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