『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.内田 大亮
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2. (英) Onoue Tomitaro (日) (読)
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[継承]
3. (英) Begum Nasima-Mila (日) (読)
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[継承]
4. (英) Kuribayashi Nobuyuki (日) (読)
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[継承]
5. (英) Tomizuka Yoshifumi (日) (読)
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6.玉谷 哲也
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学籍番号 (推奨):
[継承]
7.永井 宏和
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8.宮本 洋二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔外科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Vesnarinone downregulates CXCR4 expression via upregulation of Krüppel-like factor 2 in oral cancer cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) BACKGROUND: We have demonstrated that the stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system is involved in the establishment of lymph node metastasis in oral squamous cell carcinoma (SCC). Chemotherapy is a powerful tool for the treatment of oral cancer, including oral SCC; however, the effects of chemotherapeutic agents on the expression of CXCR4 are unknown. In this study, we examined the expression of CXCR4 associated with the chemotherapeutic agents in oral cancer cells. RESULTS: The expression of CXCR4 was examined using 3 different chemotherapeutic agents; 5-fluorouracil, cisplatin, and vesnarinone (3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2-(1H)-quinolinone) in B88, a line of oral cancer cells that exhibits high levels of CXCR4 and lymph node metastatic potential. Of the 3 chemotherapeutic agents that we examined, only vesnarinone downregulated the expression of CXCR4 at the mRNA as well as the protein level. Vesnarinone significantly inhibited lymph node metastasis in tumor-bearing nude mice. Moreover, vesnarinone markedly inhibited 2.7-kb human CXCR4 promoter activity, and we identified the transcription factor, Krüppel-like factor 2 (KLF2), as a novel vesnarinone-responsive molecule, which was bound to the CXCR4 promoter at positions -300 to -167 relative to the transcription start site. The forced-expression of KLF2 led to the downregulation of CXCR4 mRNA and impaired CXCR4 promoter activity. The use of siRNA against KLF2 led to an upregulation of CXCR4 mRNA. CONCLUSION: These Results indicate that vesnarinone downregulates CXCR4 via the upregulation of KLF2 in oral cancer.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antineoplastic Agents (日) (読) [継承]
3. (英) Cell Line, Tumor (日) (読) [継承]
4. (英) Cell Movement (日) (読) [継承]
5. (英) Cisplatin (日) (読) [継承]
6. (英) Down-Regulation (日) (読) [継承]
7. (英) Flow Cytometry (日) (読) [継承]
8. (英) Fluorouracil (日) (読) [継承]
9. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
10. (英) Hela Cells (日) (読) [継承]
11. (英) Humans (日) (読) [継承]
12. (英) Kruppel-Like Transcription Factors (日) (読) [継承]
13. (英) Luciferases (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Mice, Inbred BALB C (日) (読) [継承]
16. (英) Mice, Nude (日) (読) [継承]
17. (英) Mouth Neoplasms (日) (読) [継承]
18. (英) Oligonucleotide Array Sequence Analysis (日) (読) [継承]
19. (英) Promoter Regions, Genetic (日) (読) [継承]
20. (英) Quinolines (日) (読) [継承]
21. (英) RNA Interference (日) (読) [継承]
22. (英) Receptors, CXCR4 (日) (読) [継承]
23. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
24. (英) Tumor Burden (日) (読) [継承]
25. (英) Xenograft Model Antitumor Assays (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Molecular Cancer ([BioMed Central Ltd.])
(eISSN: 1476-4598)

ISSN (任意): 1476-4598
ISSN: 1476-4598 (eISSN: 1476-4598)
Title: Molecular cancer
Title(ISO): Mol. Cancer
Publisher: BioMed Central
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 8 [継承]
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(必須): 62 62 [継承]
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年月日 (必須): 西暦 2009年 8月 12日 (平成 21年 8月 12日) [継承]
URL (任意):
DOI (任意): 10.1186/1476-4598-8-62    (→Scopusで検索) [継承]
PMID (任意): 19671192    (→Scopusで検索) [継承]
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WOS (任意): 000269948900001 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Oral Surgery, Division of Integrated Sciences of Translational Research, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. daisuke@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC2738650  (日)    [継承]

標準的な表示

和文冊子 ● Daisuke Uchida, Tomitaro Onoue, Nasima-Mila Begum, Nobuyuki Kuribayashi, Yoshifumi Tomizuka, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Vesnarinone downregulates CXCR4 expression via upregulation of Krüppel-like factor 2 in oral cancer cells., Molecular Cancer, Vol.8, (号), 62, 2009.
欧文冊子 ● Daisuke Uchida, Tomitaro Onoue, Nasima-Mila Begum, Nobuyuki Kuribayashi, Yoshifumi Tomizuka, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Vesnarinone downregulates CXCR4 expression via upregulation of Krüppel-like factor 2 in oral cancer cells., Molecular Cancer, Vol.8, (号), 62, 2009.

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