| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): | □ | 研究生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Huang Huiwei (日) (読)
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| 2. | (英) He Jianghong (日) (読)
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| 3. | (英) Yuan Ying (日) (読)
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| 4. | (英) Aoyagi Eriko (日) (読)
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| 5. | (英) Takenaka Hidetaka (日) (読)
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| 6. | (英) Itagaki Tatuzo (日) (読)
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| 7. | (英) Sannomiya Katsutaka (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 8. | 玉木 克佳
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| 9. | (英) Harada Nagakatsu (日) (読)
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| 10. | 庄野 正行 ([徳島大学.大学院医歯薬学研究部.医学域.総合研究支援センター])
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| ○学籍番号 (推奨): |
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| 11. | 清水 一郎
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 12. | 高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Opposing effects of estradiol and progesterone on the oxidative stress-induced production of chemokine and proinflammatory cytokines in murine peritoneal macrophages. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) In inflammatory and oxidative liver injury, virus proteins and reactive oxygen species are involved in the regulation of proinflammatory cytokine production by macrophages. This study investigated the effects of estradiol (E2) and progesterone on the unstimulated and oxidative stress-stimulated production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, macrophage inflammatory protein (MIP)-2, and macrophage chemotactic protein (MCP)-1 by peritoneal macrophages isolated from male and female mice. E2 inhibited the cytokine production of TNF-alpha, IL-1beta, MIP-2, and MCP-1 by the unstimulated macrophages from males and females, which was then further stimulated by progesterone. The exposure to hydrogen peroxide in the macrophages from both sexes induced the production of cytokine. The hydrogen peroxide-stimulated cytokine production was suppressed by E2 and enhanced by progesterone. The sex hormone effects on the unstimulated and stimulated macrophages were blocked by their receptor antagonists and showed no significant difference between male and female subjects. These findings suggest that E2 may play a favorable role in the course of persistent liver injury, by inhibiting proinflammatory cytokine production, which, in addition, progesterone may counteract the favorable E2 effects through their receptors. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cells, Cultured (日) (読)
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| 3. | (英) Chemokines (日) (読)
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| 4. | 細胞質分裂 (cytokinesis)
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| 5. | (英) Depression, Chemical (日) (読)
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| 6. | (英) Estradiol (日) (読)
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| 7. | (英) Female (日) (読)
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| 8. | (英) Inflammation (日) (読)
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| 9. | (英) Inflammation Mediators (日) (読)
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| 10. | (英) Macrophages, Peritoneal (日) (読)
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| 11. | (英) Male (日) (読)
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| 12. | (英) Mice (日) (読)
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| 13. | (英) Mice, Inbred C3H (日) (読)
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| 14. | 酸化ストレス (oxidative stress)
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| 15. | (英) Progesterone (日) (読)
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| 16. | (英) Stimulation, Chemical (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1343-1420
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
(Webcat Plus)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 55
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| ○号 (必須): | □ | 1-2
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| ○頁 (必須): | □ | 133 141
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 2月 初日 (平成 20年 2月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.55.133 (→Scopusで検索)
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| ○PMID (任意): | □ | 18319556 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○機関リポジトリ : | □ | 110850
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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