『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=210324EID:210324, Map:0, LastModified:2012年9月4日(火) 14:03:04, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[庄野 正行], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨): 研究生による研究報告 [継承]
組織 (推奨):
著者 (必須): 1. (英) Azuma M. (日) (読)
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2.西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
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3. (英) Aono Y. (日) (読)
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4. (英) Inayama M. (日) (読)
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5. (英) Makino H. (日) (読)
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6.岸 潤
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7.庄野 正行 ([徳島大学.大学院医歯薬学研究部.医学域.総合研究支援センター])
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8.木下 勝弘
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9. (英) Uehara H. (日) (読)
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10. (英) ogushi H. (日) (読)
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11. (英) Izumi K. (日) (読)
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12.曽根 三郎
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題名 (必須): (英) Role of 1-acid glycoprorein in theraqeutic antifibrotic effects of imatinib plus macrolides in mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Imatinib is an inhibitor of platelet-derived growth factor receptors. We have reported that treatment with imatinib inhibited bleomycin-induced pulmonary fibrosis in mice. However, late treatment with imatinib had no effect. To clarify why imatinib had no antifibrotic effect when its administration was delayed, we focused on alpha(1)-acid glycoprotein (AGP), because it was reported to bind imatinib and mediate drug resistance. The concentration of AGP in serum of mice and patients with idiopathic pulmonary fibrosis was measured by radial immunodiffusion testing. The effects of AGP in vitro were evaluated by assaying the growth of lung fibroblasts. We examined the combined effects of erythromycin (EM) or clarithromycin (CAM) on bleomycin-induced pulmonary fibrosis in mice. Addition of AGP abrogated imatinib-mediated inhibition of the growth of fibroblasts. However, treatment with EM or CAM restored the growth-inhibitory effects of imatinib. The elevated level of AGP was detected in serum and lung homogenates in bleomycin-exposed mice and reached a plateau on Day 14. Imatinib alone did not ameliorate pulmonary fibrosis when treatment was started on Day 15, whereas coadministration of imatinib and EM or CAM significantly reduced the fibrogenesis via inhibition of the growth of fibroblasts in vivo. Serum levels of AGP were higher in patients with idiopathic pulmonary fibrosis than in healthy subjects. AGP is an important regulatory factor modulating the ability of imatinib to prevent pulmonary fibrosis in mice, and combined therapy with imatinib and EM or CAM might be useful for treatment of pulmonary fibrosis.  (日)    [継承]
キーワード (推奨): 1. (英) 1-acid glycoprorein (日) (読) [継承]
2. (英) mice (日) (読) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Respiratory and Critical Care Medicine (American Thoracic Society/American Lung Association)
(pISSN: 1073-449X, eISSN: 1535-4970)

ISSN (任意): 1535-4970
ISSN: 1073-449X (pISSN: 1073-449X, eISSN: 1535-4970)
Title: American journal of respiratory and critical care medicine
Title(ISO): Am J Respir Crit Care Med
Publisher: American Thoracic Society
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(必須): 1243 1250 [継承]
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年月日 (必須): 西暦 2007年 8月 23日 (平成 19年 8月 23日) [継承]
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DOI (任意): 10.1164/rccm.200702-178OC    (→Scopusで検索) [継承]
PMID (任意): 17717205    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Internal Medicine and Molecular Therapeutics, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● M. Azuma, Yasuhiko Nishioka, Y. Aono, M. Inayama, H. Makino, Jun Kishi, Masayuki Shono, Katsuhiro Kinoshita, H. Uehara, H. ogushi, K. Izumi and Saburo Sone : Role of 1-acid glycoprorein in theraqeutic antifibrotic effects of imatinib plus macrolides in mice., American Journal of Respiratory and Critical Care Medicine, Vol.176, No.12, 1243-1250, 2007.
欧文冊子 ● M. Azuma, Yasuhiko Nishioka, Y. Aono, M. Inayama, H. Makino, Jun Kishi, Masayuki Shono, Katsuhiro Kinoshita, H. Uehara, H. ogushi, K. Izumi and Saburo Sone : Role of 1-acid glycoprorein in theraqeutic antifibrotic effects of imatinib plus macrolides in mice., American Journal of Respiratory and Critical Care Medicine, Vol.176, No.12, 1243-1250, 2007.

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