| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): | □ | 研究生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Inoue Hiroshi (日) (読)
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| 2. | 清水 一郎
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| 3. | (英) Lu Guangming (日) (読)
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| 4. | (英) Itonaga Mina (日) (読)
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| 5. | (英) Cui Xuezhi (日) (読)
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| 6. | 岡村 住人
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| 7. | 庄野 正行 ([徳島大学.大学院医歯薬学研究部.医学域.総合研究支援センター])
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| 8. | 本田 浩仁
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| 9. | (英) Inoue Satoshi (日) (読)
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| 10. | (英) Muramatsu Masami (日) (読)
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| 11. | 伊東 進
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| ○題名 (必須): | □ | (英) Idoxifene and Estradiol Enhance Antiapoptotic Activity Through Estrogen Receptor- in Cultured Rat Hepatocytes (日)
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| ○要約 (任意): | □ | (英) Oxidative stress plays a causative role in the development of hepatic fibrosis and apoptosis. Estradiol (E2) is an antioxidant, and idoxifene is a tissue-specific selective estrogen-receptor modulator. We have previously demonstrated that E2 inhibits hepatic fibrosis in rat models of hepatic fibrosis and that the actions of E2 are mediated through estrogen receptors (ERs). This study reports on the antiapoptotic role of idoxifene and E2, and the functions of ER subtypes ER-alpha and ER-beta in hepatocytes undergoing oxidative stress. Lipid peroxidation was induced in cultured rat hepatocytes with ferric nitrilotriacetate solution with idoxifene or E2. Oxidative stress-induced early apoptosis was linked to its ability to inhibit not only the expression of Bcl-2 and Bcl-XL but the production of antioxidant enzymes as well and to stimulate Bad expression. Hepatocytes possessed functional ER-beta, but not ER-alpha, to respond directly to idoxifene and E2. Idoxifene and E2 suppressed oxidative stress-induced reactive oxygen species generation and lipid peroxidation, and their antiapoptotic effects on the activation of activator protein-1 and nuclear factor-kappaB, the loss of antioxidant enzyme activity, and Bcl-2 family protein expression in early apoptotic hepatocytes were blocked by the pure ER antagonist ICI 182,780. Our results indicate that idoxifene and E2 could enhance antiapoptotic activity through ER-beta during oxidative damage in hepatocytes. (日)
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| ○キーワード (推奨): | 1. | (英) Hepatocytes (日) (読)
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| 2. | (英) Estrogen Receptor (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Digestive Diseases and Sciences (Gastroenterology Research Group)
(pISSN: 0163-2116, eISSN: 1573-2568)
| ○ISSN (任意): | □ | 0163-2116
ISSN: 0163-2116
(pISSN: 0163-2116, eISSN: 1573-2568) Title: Digestive diseases and sciencesTitle(ISO): Dig Dis SciSupplier: Kluwer OnlinePublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 48
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 570 580
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2003年 3月 初日 (平成 15年 3月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1023/A:1022553119715 (→Scopusで検索)
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| ○PMID (任意): | □ | 12757172 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000181086900021
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Digestive and Cardiovascular Medicine, Tokushima University School of Medicine, Kuramoto-cho, Tokushima 770-8503, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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