| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): | □ | 研究生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Zhou Yajun (日) (読)
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| 2. | 清水 一郎
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| 3. | (英) Lu Guangming (日) (読)
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| 4. | (英) Itonaga Mina (日) 糸永 美奈 (読)
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| 5. | 岡村 住人
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| 6. | 庄野 正行 ([徳島大学.大学院医歯薬学研究部.医学域.総合研究支援センター])
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| 7. | 本田 浩仁
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| 8. | (英) Inoue Shuji (日) 井上 修志 (読)
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| 9. | (英) Muramatsu Masami (日) (読)
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| 10. | 伊東 進
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| ○題名 (必須): | □ | (英) Hepatic Stellate Cells Contain the Functional Estrogen Receptor β but Not the Estrogen Receptor α in Male and Female Rats (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) In an earlier study, we showed that estradiol (E2) inhibits proliferation and transformation in cultured rat hepatic stellate cells (HSCs) and that the actions of E2 are mediated through estrogen receptors (ERs). This study reports on an investigation of the cellular localization of ER subtypes ERalpha and ERbeta using immunohistochemistry in experimental fibrotic liver rats and of each ER subtype expression in cultured rat HSCs by evaluating the produced mRNA and protein. The results indicate that high levels of ERbeta expression and low or no levels of ERalpha expression were observed in normal and fibrotic livers and in quiescent and activated HSCs from both males and females. The specificity of E2-mediated antiapoptotic induction through the ERbeta was shown by dose-dependent inhibition by the pure ER antagonist ICI 182,780 in HSCs which were undergoing early apoptosis. These findings demonstrate for the first time that rat HSCs possess functional Erbeta, but not Eralpha, to respond directly to E2 exposure. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | アポトーシス (apoptosis)
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| 3. | (英) Binding, Competitive (日) (読)
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| 4. | (英) Blotting, Western (日) (読)
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| 5. | 細胞分裂 (cell division)
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| 6. | (英) Cells, Cultured (日) (読)
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| 7. | (英) Dose-Response Relationship, Drug (日) (読)
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| 8. | (英) Estradiol (日) (読)
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| 9. | (英) Estrogen Receptor alpha (日) (読)
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| 10. | (英) Estrogen Receptor beta (日) (読)
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| 11. | 女性 (female)
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| 12. | (英) Flow Cytometry (日) (読)
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| 13. | (英) Fulvestrant (日) (読)
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| 14. | (英) Hepatocytes (日) (読)
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| 15. | 免疫組織化学 (immunohistochemistry)
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| 16. | (英) Liver (日) (読)
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| 17. | (英) Male (日) (読)
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| 18. | (英) Membrane Potentials (日) (読)
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| 19. | (英) Microscopy, Confocal (日) (読)
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| 20. | (英) Proto-Oncogene Proteins c-bcl-2 (日) (読)
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| 21. | (英) RNA, Messenger (日) (読)
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| 22. | (英) Rats (日) (読)
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| 23. | (英) Rats, Wistar (日) (読)
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| 24. | (英) Receptors, Estrogen (日) (読)
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| 25. | (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読)
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| 26. | (英) Sex Factors (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)
| ○ISSN (任意): | □ | 0006-291X
ISSN: 0006-291X
(pISSN: 0006-291X, eISSN: 1090-2104) Title: Biochemical and biophysical research communicationsTitle(ISO): Biochem Biophys Res CommunPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 286
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 1059 1065
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2001年 9月 7日 (平成 13年 9月 7日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1006/bbrc.2001.5479 (→Scopusで検索)
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| ○PMID (任意): | □ | 11527408 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-0034816505
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| ○researchmap (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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