『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=210018)

EID=210018EID:210018, Map:0, LastModified:2014年2月27日(木) 19:53:15, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.落合 和彦
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Morimatsu Masami (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Yoshikawa Yasunaga (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Syuto Bunei (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Hashizume Kazuyoshi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Brca2 C-terminus interacts with Rad51 and contributes to nuclear focus formation in double-strand repair of DNA.  (日)    [継承]
副題 (任意):
要約 (任意): (英) In humans and mice, the interaction between the breast cancer susceptibility protein, BRCA2, and RAD51 recombinase is essential for DNA repair by homologous recombination, the failure of this process can predispose to cancer. Cells with mutated BRCA2 are hypersensitive to ionizing radiation (IR) and exhibit defective DNA repair. Using yeast and mammalian two-hybrid assays, we demonstrate that canine Rad51 protein interacts specifically with the C-terminus of canine Brca2. In support of the biological significance of this interaction, we found that radiation-induced focus formation of Rad51 in COS-7 cells was compromised by forced expression of the C-terminus of canine Brca2. A similar result was obtained for the murine C-terminus. These data suggest that the C-terminal domain of canine Brca2 functions to bind Rad51 and that this domain contributes to the IR-induced assembly of the Rad51 complex in vivo.  (日)    [継承]
キーワード (推奨): 1. (英) Brca2 (日) (読) [継承]
2. (英) C-term (日) (読) [継承]
3. (英) canine (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biomedical Research (Biomedical Research Foundation (Japan))
(pISSN: 0388-6107, eISSN: 1880-313X)

ISSN (任意): 0388-6107
ISSN: 0388-6107 (pISSN: 0388-6107, eISSN: 1880-313X)
Title: Biomedical research (Tokyo, Japan)
Title(ISO): Biomed Res
Supplier: バイオメディカルリサーチプレス
Publisher: Biomedical Research Foundation
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 25 [継承]
(必須): 6 [継承]
(必須): 269 275 [継承]
都市 (任意):
年月日 (必須): 西暦 2004年 12月 初日 (平成 16年 12月 初日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/80017125652/ [継承]
DOI (任意):
PMID (任意):
NAID (任意): 80017125652 [継承]
WOS (任意): 000238555000004 [継承]
Scopus (任意): 2-s2.0-27244456612 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意):

標準的な表示

和文冊子 ● Kazuhiko Ochiai, Masami Morimatsu, Yasunaga Yoshikawa, Bunei Syuto and Kazuyoshi Hashizume : Brca2 C-terminus interacts with Rad51 and contributes to nuclear focus formation in double-strand repair of DNA., Biomedical Research, Vol.25, No.6, 269-275, 2004.
欧文冊子 ● Kazuhiko Ochiai, Masami Morimatsu, Yasunaga Yoshikawa, Bunei Syuto and Kazuyoshi Hashizume : Brca2 C-terminus interacts with Rad51 and contributes to nuclear focus formation in double-strand repair of DNA., Biomedical Research, Vol.25, No.6, 269-275, 2004.

関連情報

Number of session users = 0, LA = 0.88, Max(EID) = 382774, Max(EOID) = 1022369.