『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Sakaguchi Masakiyo (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Kataoka Ken (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Abarzua Fernando (日) (読)
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[継承]
4. (英) Tanimoto Ryuta (日) (読)
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[継承]
5. (英) Watanabe Masami (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Murata Hitoshi (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Than Swe Swe (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Kurose Kaoru (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Kashiwakura Yuji (日) (読)
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学籍番号 (推奨):
[継承]
10.落合 和彦
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[継承]
11. (英) Nasu Yasutomo (日) (読)
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[継承]
12. (英) Kumon Hiromi (日) (読)
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[継承]
13. (英) Huh Nam-ho (日) (読)
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[継承]
題名 (必須): (英) Overexpression of REIC/Dkk-3 in normal fibroblasts suppresses tumor growth via induction of interleukin-7.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We previously showed that the tumor suppressor gene REIC/Dkk-3, when overexpressed by an adenovirus (Ad-REIC), exhibited a dramatic therapeutic effect on human cancers through a mechanism triggered by endoplasmic reticulum stress. Adenovirus vectors show no target cell specificity and thus may elicit unfavorable side effects through infection of normal cells even upon intra-tumoral injection. In this study, we examined possible effects of Ad-REIC on normal cells. We found that infection of normal human fibroblasts (NHF) did not cause apoptosis but induced production of interleukin (IL)-7. The induction was triggered by endoplasmic reticulum stress and mediated through IRE1alpha, ASK1, p38, and IRF-1. When Ad-REIC-infected NHF were transplanted in a mixture with untreated human prostate cancer cells, the growth of the cancer cells was significantly suppressed. Injection of an IL-7 antibody partially abrogated the suppressive effect of Ad-REIC-infected NHF. These results indicate that Ad-REIC has another arm against human cancer, an indirect host-mediated effect because of overproduction of IL-7 by mis-targeted NHF, in addition to its direct effect on cancer cells.  (日)    [継承]
キーワード (推奨): 1. (英) Adenoviridae (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Cell Line, Tumor (日) (読) [継承]
4. (英) Cell Proliferation (日) (読) [継承]
5.小胞体 (endoplasmic reticulum) [継承]
6. (英) Fibroblasts (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Intercellular Signaling Peptides and Proteins (日) (読) [継承]
9. (英) Interferon Regulatory Factor-1 (日) (読) [継承]
10. (英) Interleukin-7 (日) (読) [継承]
11. (英) MAP Kinase Kinase Kinase 5 (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Neoplasms (日) (読) [継承]
14. (英) STAT1 Transcription Factor (日) (読) [継承]
15.シグナル伝達 (signal transduction) [継承]
16. (英) p38 Mitogen-Activated Protein Kinases (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)

ISSN (任意): 0021-9258
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 284 [継承]
(必須): 21 [継承]
(必須): 14236 14244 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 3月 11日 (平成 21年 3月 11日) [継承]
URL (任意):
DOI (任意): 10.1074/jbc.M808002200    (→Scopusで検索) [継承]
PMID (任意): 19279003    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikatachou, Okayama 700-8558, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC2682872  (日)    [継承]

標準的な表示

和文冊子 ● Masakiyo Sakaguchi, Ken Kataoka, Fernando Abarzua, Ryuta Tanimoto, Masami Watanabe, Hitoshi Murata, Swe Swe Than, Kaoru Kurose, Yuji Kashiwakura, Kazuhiko Ochiai, Yasutomo Nasu, Hiromi Kumon and Nam-ho Huh : Overexpression of REIC/Dkk-3 in normal fibroblasts suppresses tumor growth via induction of interleukin-7., The Journal of Biological Chemistry, Vol.284, No.21, 14236-14244, 2009.
欧文冊子 ● Masakiyo Sakaguchi, Ken Kataoka, Fernando Abarzua, Ryuta Tanimoto, Masami Watanabe, Hitoshi Murata, Swe Swe Than, Kaoru Kurose, Yuji Kashiwakura, Kazuhiko Ochiai, Yasutomo Nasu, Hiromi Kumon and Nam-ho Huh : Overexpression of REIC/Dkk-3 in normal fibroblasts suppresses tumor growth via induction of interleukin-7., The Journal of Biological Chemistry, Vol.284, No.21, 14236-14244, 2009.

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