『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Kawasaki K (日) (読)
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2. (英) Watanabe M (日) (読)
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3. (英) Sakaguchi M (日) (読)
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[継承]
4. (英) Ogasawara Y (日) (読)
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5.落合 和彦
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6. (英) Nasu Y (日) (読)
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7. (英) Doihara H (日) (読)
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8. (英) Kashiwakura Y (日) (読)
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9. (英) Huh N-h (日) (読)
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10. (英) Kumon H (日) (読)
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11. (英) Date H (日) (読)
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題名 (必須): (英) REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The overexpression of reduced expression in immortalized cells (REIC)/Dickkopf-3 (Dkk-3), a tumor suppressor gene, induced apoptosis in human prostatic and testicular cancer cells. The aim of this study is to examine the potential of REIC/Dkk-3 as a therapeutic target against breast cancer. First, the in vitro apoptotic effect of Ad-REIC treatment was investigated in breast cancer cell lines and the adenovirus-mediated overexpression of REIC/Dkk-3 was thus found to lead to apoptotic cell death in a c-Jun-NH(2)-kinase (JNK) phosphorylaion-dependent manner. Moreover, an in vivo apoptotic effect and MCF/Wt tumor growth inhibition were observed in the mouse model after intratumoral Ad-REIC injection. As multidrug resistance (MDR) is a major problem in the chemotherapy of progressive breast cancer, the in vitro effects of Ad-REIC treatment were investigated in terms of the sensitivity of multidrug-resistant MCF7/ADR cells to doxorubicin and of the P-glycoprotein expression. Ad-REIC treatment in MCF7/ADR cells also downregulated P-glycoprotein expresssion through JNK activation, and sensitized its drug resistance against doxorubicin. Therefore, not only apoptosis induction but also the reversal of anticancer drug resistance was achieved using Ad-REIC. We suggest that REIC/Dkk-3 is a novel target for breast cancer treatment and that Ad-REIC might be an attractive agent against drug-resistant cancer in combination with conventional antineoplastic agents.  (日)    [継承]
キーワード (推奨): 1. (英) Adenoviridae (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Antibiotics, Antineoplastic (日) (読) [継承]
4.アポトーシス (apoptosis) [継承]
5. (英) Breast Neoplasms (日) (読) [継承]
6. (英) Down-Regulation (日) (読) [継承]
7. (英) Doxorubicin (日) (読) [継承]
8. (英) Drug Resistance, Multiple (日) (読) [継承]
9. (英) Drug Resistance, Neoplasm (日) (読) [継承]
10. (英) Enzyme Activation (日) (読) [継承]
11. (英) Female (日) (読) [継承]
12.遺伝子治療 (gene therapy) [継承]
13. (英) Hela Cells (日) (読) [継承]
14. (英) Humans (日) (読) [継承]
15. (英) Intercellular Signaling Peptides and Proteins (日) (読) [継承]
16. (英) MAP Kinase Kinase 4 (日) (読) [継承]
17. (英) Mice (日) (読) [継承]
18. (英) Mice, Nude (日) (読) [継承]
19. (英) Neoplasm Transplantation (日) (読) [継承]
20. (英) P-Glycoprotein (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cancer Gene Therapy ([Nature Publishing Group])
(pISSN: 0929-1903, eISSN: 1476-5500)

ISSN (任意): 1476-5500
ISSN: 0929-1903 (pISSN: 0929-1903, eISSN: 1476-5500)
Title: Cancer gene therapy
Title(ISO): Cancer Gene Ther
Publisher: Springer Nature
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2008年 7月 25日 (平成 20年 7月 25日) [継承]
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DOI (任意): 10.1038/cgt.2008.58    (→Scopusで検索) [継承]
PMID (任意): 18654608    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● K Kawasaki, M Watanabe, M Sakaguchi, Y Ogasawara, Kazuhiko Ochiai, Y Nasu, H Doihara, Y Kashiwakura, N-h Huh, H Kumon and H Date : REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer., Cancer Gene Therapy, Vol.16, No.1, 65-72, 2008.
欧文冊子 ● K Kawasaki, M Watanabe, M Sakaguchi, Y Ogasawara, Kazuhiko Ochiai, Y Nasu, H Doihara, Y Kashiwakura, N-h Huh, H Kumon and H Date : REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer., Cancer Gene Therapy, Vol.16, No.1, 65-72, 2008.

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