『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Oonuma Toshina (日) (読)
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2. (英) Morimatsu Masami (日) (読)
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3.落合 和彦
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4. (英) Iwanaga Toshihiko (日) (読)
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5. (英) Hashizume Kazuyoshi (日) (読)
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題名 (必須): (英) Role of NF-kappaB in constitutive expression of MAIL in epidermal keratinocytes.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Molecule possessing ankyrin-repeats induced by lipopolysaccharide (MAIL) is a nuclear IkappaB protein that is also known as interleukin-1-inducible nuclear ankyrin repeat protein and inhibitor of nuclear factor kappaBzeta (IkappaBzeta). We previously observed that MAIL-deficient mice were affected by atopic dermatitis-like skin lesions and demonstrated the importance of MAIL in the skin. In this study, we investigated MAIL expression in mouse keratinocytes. MAIL mRNA was constitutively expressed in the skin epidermis. MAIL expression was also confirmed in primary keratinocytes and the PAM212 keratinocyte cell line. The inhibitors of nuclear factor kappaB (NF-kappaB)-Bay11-7082 and the IkappaBalphaM supersuppressor-considerably downregulated MAIL expression in the keratinocytes. Immunoreactivity for NF-kappaB components was localized in the cytoplasm and nucleus of normal unstimulated keratinocytes. The expression level of MAIL in the skin did not change following lipopolysaccharide (LPS) administration to mice. Interestingly, in accordance with the in vivo findings, the MAIL expression level did not change following LPS stimulation even in primary keratinocytes; however, MAIL expression was strongly increased by interleukin-1 stimulation. These results collectively suggest that the constitutive expression of MAIL in keratinocytes is controlled, at least in part, by NF-kappaB and that there may be LPS-specific repressive mechanisms that inhibit MAIL induction.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cell Line (日) (読) [継承]
3. (英) DNA Primers (日) (読) [継承]
4.免疫組織化学 (immunohistochemistry) [継承]
5. (英) Interleukin-1 (日) (読) [継承]
6. (英) Keratinocytes (日) (読) [継承]
7. (英) Lipopolysaccharides (日) (読) [継承]
8. (英) Luciferases (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Mice, Inbred C57BL (日) (読) [継承]
12. (英) Microscopy, Fluorescence (日) (読) [継承]
13. (英) NF-kappa B (日) (読) [継承]
14. (英) Nuclear Proteins (日) (読) [継承]
15. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Veterinary Medical Science ([社団法人 日本獣医学会])
(pISSN: 0916-7250, eISSN: 1347-7439)

ISSN (任意): 0916-7250
ISSN: 0916-7250 (pISSN: 0916-7250, eISSN: 1347-7439)
Title: The Journal of veterinary medical science
Title(ISO): J Vet Med Sci
Supplier: 社団法人日本獣医学会
Publisher: Maruzen Co., Ltd/Maruzen Kabushikikaisha
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 69 [継承]
(必須): 3 [継承]
(必須): 279 284 [継承]
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年月日 (必須): 西暦 2007年 3月 初日 (平成 19年 3月 初日) [継承]
URL (任意):
DOI (任意): 10.1292/jvms.69.279    (→Scopusで検索) [継承]
PMID (任意): 17409644    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: United Graduate School of Veterinary Science, Gifu University, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Toshina Oonuma, Masami Morimatsu, Kazuhiko Ochiai, Toshihiko Iwanaga and Kazuyoshi Hashizume : Role of NF-kappaB in constitutive expression of MAIL in epidermal keratinocytes., The Journal of Veterinary Medical Science, Vol.69, No.3, 279-284, 2007.
欧文冊子 ● Toshina Oonuma, Masami Morimatsu, Kazuhiko Ochiai, Toshihiko Iwanaga and Kazuyoshi Hashizume : Role of NF-kappaB in constitutive expression of MAIL in epidermal keratinocytes., The Journal of Veterinary Medical Science, Vol.69, No.3, 279-284, 2007.

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