『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Yoshikawa Yasunaga (日) (読)
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2. (英) Morimatsu Masami (日) (読)
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3.落合 和彦
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4. (英) Nagano Masashi (日) (読)
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5. (英) Yamane Yoshihisa (日) (読)
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6. (英) Tomizawa Nobuyuki (日) (読)
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7. (英) Sasaki Nobuo (日) (読)
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8. (英) Hashizume Kazuyoshi (日) (読)
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題名 (必須): (英) Analysis of genetic variations in the exon 27 region of the canine BRCA2 locus.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Mammary tumors are the most common tumor type in women as well as in female dogs. The BRCA2 gene encodes a large nuclear protein that is involved in DNA repair, and mutations in the human BRCA2 confer an increased risk of female mammary tumors. The BRCA2 protein acts as a tumor suppressor, and inactivation of BRCA2 by loss of heterozygosity is implicated in mammary carcinogenesis. In this study, to establish an appropriate polymorphic marker for loss of heterozygosity analysis of the canine BRCA2, we analyzed the genomic sequences of the exon 27 regions of 30 mammary-tumor-bearing and 21 tumor-free dogs. In addition to 10204ins/delAAA, which is the only polymorphism previously identified for the canine BRCA2 locus, we discovered four novel single nucleotide polymorphisms. The analysis of these five polymorphisms revealed the presence of four allele types. Since 10204ins/delAAA was the most common of the five polymorphisms identified, we developed a PCR-based assay method to assay for this polymorphism. We believe that this method is valuable for loss of heterozygosity analysis of the canine BRCA2 gene in tumor pathogenesis.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Base Sequence (日) (読) [継承]
3. (英) Breast Neoplasms (日) (読) [継承]
4. (英) DNA Primers (日) (読) [継承]
5. (英) Dog Diseases (日) (読) [継承]
6. (英) Dogs (日) (読) [継承]
7. (英) Exons (日) (読) [継承]
8. (英) Genes, BRCA2 (日) (読) [継承]
9. (英) Molecular Sequence Data (日) (読) [継承]
10. (英) Mutation (日) (読) [継承]
11. (英) Polymorphism, Genetic (日) (読) [継承]
12. (英) Sequence Analysis, DNA (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Veterinary Medical Science ([社団法人 日本獣医学会])
(pISSN: 0916-7250, eISSN: 1347-7439)

ISSN (任意): 0916-7250
ISSN: 0916-7250 (pISSN: 0916-7250, eISSN: 1347-7439)
Title: The Journal of veterinary medical science
Title(ISO): J Vet Med Sci
Supplier: 社団法人日本獣医学会
Publisher: Maruzen Co., Ltd/Maruzen Kabushikikaisha
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 67 [継承]
(必須): 10 [継承]
(必須): 1013 1017 [継承]
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年月日 (必須): 西暦 2005年 10月 初日 (平成 17年 10月 初日) [継承]
URL (任意):
DOI (任意): 10.1292/jvms.67.1013    (→Scopusで検索) [継承]
PMID (任意): 16276057    (→Scopusで検索) [継承]
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WOS (任意): 000233351400008 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yasunaga Yoshikawa, Masami Morimatsu, Kazuhiko Ochiai, Masashi Nagano, Yoshihisa Yamane, Nobuyuki Tomizawa, Nobuo Sasaki and Kazuyoshi Hashizume : Analysis of genetic variations in the exon 27 region of the canine BRCA2 locus., The Journal of Veterinary Medical Science, Vol.67, No.10, 1013-1017, 2005.
欧文冊子 ● Yasunaga Yoshikawa, Masami Morimatsu, Kazuhiko Ochiai, Masashi Nagano, Yoshihisa Yamane, Nobuyuki Tomizawa, Nobuo Sasaki and Kazuyoshi Hashizume : Analysis of genetic variations in the exon 27 region of the canine BRCA2 locus., The Journal of Veterinary Medical Science, Vol.67, No.10, 1013-1017, 2005.

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