『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.落合 和彦
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2. (英) Morimatsu Masami (日) (読)
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3. (英) Tomizawa Nobuyuki (日) (読)
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4. (英) Syuto Bunei (日) (読)
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題名 (必須): (英) Cloning and sequencing full length of canine Brca2 and Rad51 cDNA.  (日)    [継承]
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要約 (任意): (英) Mammary tumors are the most common neoplasm in female dogs, Canis canis, and in women. Mutations in human Brca2 confer an increased risk of female breast cancer. Previous studies have shown that the Brca2 tumor suppressor protein interacts with the recombinational repair protein Rad51. We cloned the full-length cDNA of the canine homologues of Brca2 and Rad51 to obtain a basis for studying their relationship with susceptibility to mammary tumors. The canine Brca2 and Rad51 cDNAs are 11 and 1.5 kb long, encoding 3.471 and 339 amino acids, respectively. The amino acid sequence of canine Brca2 showed 68% homology with the human protein, and 58% homology with a murine protein. There were highly conserved regions in the C-terminus of all three proteins, where the Rad51 interacting domain and putative nuclear localization signals are located. Comparing with the partial genomic sequence previously reported, we found possible nuclear polymorphisms in exon 11, some of which result in amino acid substitutions. On the other hand, canine Rad51 protein had extremely high homology (99%) to the human and murine proteins. Expression of both Brca2 and Rad51 was detected in the mammary gland, suggesting that these two genes interact in the canine mammary gland.  (日)    [継承]
キーワード (推奨): 1. (英) Amino Acid Sequence (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) BRCA2 Protein (日) (読) [継承]
4. (英) Base Sequence (日) (読) [継承]
5. (英) Cloning, Molecular (日) (読) [継承]
6. (英) DNA, Complementary (日) (読) [継承]
7. (英) DNA-Binding Proteins (日) (読) [継承]
8. (英) Dog Diseases (日) (読) [継承]
9. (英) Dogs (日) (読) [継承]
10. (英) Genes, BRCA2 (日) (読) [継承]
11. (英) Humans (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Mammary Neoplasms, Animal (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Molecular Sequence Data (日) (読) [継承]
16. (英) RNA, Neoplasm (日) (読) [継承]
17. (英) Rad51 Recombinase (日) (読) [継承]
18. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
19. (英) Sequence Homology, Nucleic Acid (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Veterinary Medical Science ([社団法人 日本獣医学会])
(pISSN: 0916-7250, eISSN: 1347-7439)

ISSN (任意): 0916-7250
ISSN: 0916-7250 (pISSN: 0916-7250, eISSN: 1347-7439)
Title: The Journal of veterinary medical science
Title(ISO): J Vet Med Sci
Supplier: 社団法人日本獣医学会
Publisher: Maruzen Co., Ltd/Maruzen Kabushikikaisha
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 63 [継承]
(必須): 10 [継承]
(必須): 1103 1108 [継承]
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年月日 (必須): 西暦 2001年 10月 初日 (平成 13年 10月 初日) [継承]
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PMID (任意): 11714026    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Laboratories of Veterinary Physiology, Faculty of Agriculture, Iwate University, Morioka, Japan.  (日)    [継承]
2.(英) Article.DataBankList.DataBank.DataBankName: GENBANK  (日)    [継承]
3.(英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: AB043895  (日)    [継承]
4.(英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: AB043896  (日)    [継承]
5.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
6.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kazuhiko Ochiai, Masami Morimatsu, Nobuyuki Tomizawa and Bunei Syuto : Cloning and sequencing full length of canine Brca2 and Rad51 cDNA., The Journal of Veterinary Medical Science, Vol.63, No.10, 1103-1108, 2001.
欧文冊子 ● Kazuhiko Ochiai, Masami Morimatsu, Nobuyuki Tomizawa and Bunei Syuto : Cloning and sequencing full length of canine Brca2 and Rad51 cDNA., The Journal of Veterinary Medical Science, Vol.63, No.10, 1103-1108, 2001.

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