『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=20974EID:20974, Map:0, LastModified:2013年9月11日(水) 20:32:54, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[松木 均], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.工学部.生物工学科.生物機能工学講座 [継承]
著者 (必須): 1. (英) Maruyama Shoji (日) (読)
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学籍番号 (推奨):
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2. (英) Hata Takashi (日) (読)
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3.松木 均 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意): (英)   (日) 計画,考察   [継承]
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学籍番号 (推奨):
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4.金品 昌志
役割 (任意): (英)   (日) 計画,解析,考察,論文執筆の指導   [継承]
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学籍番号 (推奨):
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題名 (必須): (英) Effects of Pressure and Local Anesthetic Tetracaine on Dipalmitoylphosphatidylcholine Bilayers  (日)    [継承]
副題 (任意):
要約 (任意): (英) The temperature-pressure phase diagram of dipalmitoylphosphatidylcholine (DPPC) multilamellar vesicles was constructed in the presence of a local anesthetic tetracaine hydrochloride (TC-HCl). The phase-transition temperatures under various pressures were determined by the method of high-pressure light transmission. The temperature of the main transition from the ripple gel (P'(beta)) to the liquid crystal (L(alpha)) phase was depressed by the addition of TC-HCl and elevated by application of pressure up to 150 MPa. The temperature of the pretransition from the lamellar gel (L'(beta)) to the P'(beta) phase was also depressed by the addition of TC-HCl below ca. 10.0 mmol kg(-1) and elevated by the pressure below ca. 50 MPa. Therefore, pressure-anesthetic antagonism for both phase-transitions was confirmed. The pressure-induced interdigitated gel (L(beta)I) phase has been observed under high pressure above 100 MPa in the absence of TC-HCl. The L(beta)I phase is known to be induced also by a variety of small amphiphilic molecules such as ethanol, benzyl alcohol and TC-HCl. In the presence of TC-HCl ranging in concentration up to 20.0 mmol kg(-1), the L(beta)I phase instead of the P'(beta) phase appeared at higher pressure. Present results revealed that pressure facilitates, rather than antagonizes, the effect of TC-HCl on the occurrence of interdigitated gel phase. Furthermore, two regions of two phase coexistence were observed under high pressure in the presence of TC-HCl. One is probably a region of coexisting L(beta)I and L(alpha) phase, which was found between L(beta)I and L(alpha) phases under various pressures. The other is probably a region of coexisting L'(beta) and L(beta)I phase, which was observed in the presence of TC-HCl up to 10.0 mmol kg(-1) at the pressure above 40 MPa and at the temperature below ca. 35 degrees C.  (日) 局所麻酔薬テトラカイン塩酸塩存在下において,ジパルミトイルホスファチジルコリン多重層ベシクルの温度-圧力相図を高圧光透過法によって構築した.主転移および前転移温度共にテトラカイン添加により降下し,加圧で上昇することから麻酔の圧拮抗現象を確認した.他方,テトラカインと加圧は,互いに指組構造のゲル相の出現を促進させた.さらにテトラカイン存在の高圧下において2つの2相共存領域を観測した.   [継承]
キーワード (推奨): 1. (英) 1,2-Dipalmitoylphosphatidylcholine (日) (読) [継承]
2. (英) Anesthetics, Local (日) (読) [継承]
3. (英) Calorimetry, Differential Scanning (日) (読) [継承]
4. (英) Lipid Bilayers (日) (読) [継承]
5. (英) Pressure (日) (読) [継承]
6. (英) Temperature (日) (読) [継承]
7. (英) Tetracaine (日) (読) [継承]
発行所 (推奨): Elsevier Science [継承]
誌名 (必須): Biochimica et Biophysica Acta (BBA) - Biomembranes ([Elsevier Science])
(pISSN: 0005-2736)

ISSN (任意): 0005-2736
ISSN: 0005-2736 (pISSN: 0005-2736, eISSN: 1879-2642)
Title: Biochimica et biophysica acta. Biomembranes
Title(ISO): Biochim Biophys Acta Biomembr
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 1997年 4月 1日 (平成 9年 4月 1日) [継承]
URL (任意):
DOI (任意): 10.1016/S0005-2736(96)00265-9    (→Scopusで検索) [継承]
PMID (任意): 9168152    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, Minamijosanjima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Shoji Maruyama, Takashi Hata, Hitoshi Matsuki and Shoji Kaneshina : Effects of Pressure and Local Anesthetic Tetracaine on Dipalmitoylphosphatidylcholine Bilayers, Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol.1325, No.2, 272-280, 1997.
欧文冊子 ● Shoji Maruyama, Takashi Hata, Hitoshi Matsuki and Shoji Kaneshina : Effects of Pressure and Local Anesthetic Tetracaine on Dipalmitoylphosphatidylcholine Bilayers, Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol.1325, No.2, 272-280, 1997.

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