『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=209467EID:209467, Map:0, LastModified:2017年12月4日(月) 14:25:51, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[細川 義隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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著者 (必須): 1.細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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2.細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学])
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3.尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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4.中西 正 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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5.中江 英明
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6.松尾 敬志
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題名 (必須): (英) Catechins inhibit CXCL10 production from oncostatin M-stimulated human gingival fibroblasts  (日)    [継承]
副題 (任意):
要約 (任意): (英) CXC chemokine ligand 10 (CXCL10) plays a pivotal role in the recruitment of Th1 cells and, thus, in the development of periodontal disease. Epigallocatechin gallate (EGCG) and epicatechin gallate (ECG), the major catechins derived from green tea, have multiple beneficial effects, but the effects of catechins on CXCL10 production from human gingival fibroblasts (HGFs) is not known. In this study, we investigated the mechanisms by which EGCG and ECG inhibit oncostatin M (OSM)-induced CXCL10 production in HGFs. HGFs constitutively expressed glycoprotein 130 and OSM receptor beta (OSMR beta), which are OSM receptors. OSM increased CXCL10 production in a concentration-dependent manner. EGCG and ECG prevented OSM-mediated CXCL10 production by HGFs. Inhibitors of p38 mitogen-activated protein kinase, c-Jun N-terminal kinase (JNK), phosphatidylinositol-3-OH kinase and signal transducer and activator of transcription (STAT)3 decreased OSM-induced CXCL10 production. EGCG significantly prevented OSM-induced phosphorylation of JNK, Akt (Ser473) and STAT3 (Tyr705 and Ser727). ECG prevented phosphorylation of JNK and Akt (Ser473). In addition, EGCG and ECG attenuated OSMR beta expression on HGFs. These data provide a novel mechanism through which the green tea flavonoids, catechins, can provide direct benefits in periodontal disease.  (日)    [継承]
キーワード (推奨): 1. (英) Anti-Inflammatory Agents, Non-Steroidal (日) (読) [継承]
2. (英) Antioxidants (日) (読) [継承]
3. (英) Catechin (日) (読) [継承]
4. (英) Cells, Cultured (日) (読) [継承]
5. (英) Chemokine CXCL10 (日) (読) [継承]
6. (英) Cytokine Receptor gp130 (日) (読) [継承]
7. (英) Enzyme Inhibitors (日) (読) [継承]
8. (英) Fibroblasts (日) (読) [継承]
9. (英) Gene Expression Regulation (日) (読) [継承]
10. (英) Gingiva (日) (読) [継承]
11. (英) Humans (日) (読) [継承]
12. (英) Oncostatin M (日) (読) [継承]
13. (英) Oncostatin M Receptor beta Subunit (日) (読) [継承]
14. (英) Osmolar Concentration (日) (読) [継承]
15. (英) Periodontal Diseases (日) (読) [継承]
16. (英) Phosphorylation (日) (読) [継承]
17. (英) Signal Transduction (日) (読) [継承]
発行所 (推奨): Wiley-Blackwell [継承]
誌名 (必須): The Journal of Nutritional Biochemistry ([Elsevier])
(pISSN: 0955-2863, eISSN: 1873-4847)

ISSN (任意): 1873-4847
ISSN: 0955-2863 (pISSN: 0955-2863, eISSN: 1873-4847)
Title: The Journal of nutritional biochemistry
Title(ISO): J. Nutr. Biochem.
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 7 [継承]
(必須): 659 664 [継承]
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年月日 (必須): 西暦 2010年 7月 初日 (平成 22年 7月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/j.jnutbio.2009.04.005    (→Scopusで検索) [継承]
PMID (任意): 19616927    (→Scopusで検索) [継承]
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WOS (任意): 000279363200013 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Conservative Dentistry and Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima 770-8504, Japan. hosokawa@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Tadashi Nakanishi, Hideaki Nakae and Takashi Matsuo : Catechins inhibit CXCL10 production from oncostatin M-stimulated human gingival fibroblasts, The Journal of Nutritional Biochemistry, Vol.21, No.7, 659-664, 2010.
欧文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Tadashi Nakanishi, Hideaki Nakae and Takashi Matsuo : Catechins inhibit CXCL10 production from oncostatin M-stimulated human gingival fibroblasts, The Journal of Nutritional Biochemistry, Vol.21, No.7, 659-664, 2010.

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