『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=209426EID:209426, Map:0, LastModified:2017年11月27日(月) 18:35:00, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[高浜 洋介], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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著者 (必須): 1.高浜 洋介
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2.新田 剛
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3. (英) MatRipen Adiratna (日) (読)
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4. (英) Nitta Sachiko (日) (読)
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5. (英) Murata Shigeo (日) (読)
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6. (英) Tanaka Keiji (日) (読)
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題名 (必須): (英) Role of thymic-cortex-specific self-peptides in positive selection of T cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) During T cell development in the thymus, a virgin repertoire of diverse TCRalphabeta recognition specificities in immature thymocytes is selected through positive and negative selection to form an immunocompetent and self-tolerant repertoire of mature T cells. Positive selection supports the survival of thymocytes that receive weak signals of low-avidity TCR engagement, whereas negative selection deletes potentially harmful self-reactive thymocytes upon high-avidity TCR engagement. Early studies have highlighted the role of TCR interaction with polymorphic MHC determinants in positive selection, while negative selection imposes TCR specificity to peptide antigens displayed by MHC molecules. However, recent advances in the biology of thymic stromal cells have indicated that the formation of an immunocompetent TCR repertoire requires positive selection by thymic cortical epithelial cells expressing a unique protein degradation machinery, suggesting the role of self-peptide repertoire specifically expressed by thymic cortical epithelial cells in the development of the acquired immune system.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Histocompatibility Antigens (日) (読) [継承]
3. (英) Humans (日) (読) [継承]
4. (英) Peptides (日) (読) [継承]
5. (英) Receptors, Antigen, T-Cell (日) (読) [継承]
6. (英) T-Lymphocytes (日) (読) [継承]
7. (英) Thymus Gland (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Seminars in Immunology ([Elsevier])
(pISSN: 1044-5323, eISSN: 1096-3618)

ISSN (任意): 1096-3618
ISSN: 1044-5323 (pISSN: 1044-5323, eISSN: 1096-3618)
Title: Seminars in immunology
Title(ISO): Semin Immunol
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 22 [継承]
(必須): 5 [継承]
(必須): 287 293 [継承]
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年月日 (必須): 西暦 2010年 5月 26日 (平成 22年 5月 26日) [継承]
URL (任意):
DOI (任意): 10.1016/j.smim.2010.04.012    (→Scopusで検索) [継承]
PMID (任意): 20510627    (→Scopusで検索) [継承]
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WOS (任意): 000281590100006 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770-8503, Japan. takahama@genome.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
5.(英) NumberOfReferences: 88  (日)    [継承]

標準的な表示

和文冊子 ● Yousuke Takahama, Takeshi Nitta, Adiratna MatRipen, Sachiko Nitta, Shigeo Murata and Keiji Tanaka : Role of thymic-cortex-specific self-peptides in positive selection of T cells., Seminars in Immunology, Vol.22, No.5, 287-293, 2010.
欧文冊子 ● Yousuke Takahama, Takeshi Nitta, Adiratna MatRipen, Sachiko Nitta, Shigeo Murata and Keiji Tanaka : Role of thymic-cortex-specific self-peptides in positive selection of T cells., Seminars in Immunology, Vol.22, No.5, 287-293, 2010.

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