『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=208863)

EID=208863EID:208863, Map:0, LastModified:2016年12月27日(火) 13:48:23, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.工学部.生物工学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 総説·解説 [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.大政 健史
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.鬼塚 正義 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Kim Wook-Dong (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Cell engineering and cultivation of Chinese hamster ovary (CHO) cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) Mammalian cell lines are important host cells for the industrial production of pharmaceutical proteins owing to their capacity for correct folding, assembly and post-translational modification. In particular, Chinese hamster ovary (CHO) cells are the most dependable host cells for the industrial production of therapeutic proteins. Growing demand for therapeutic proteins promotes the development of technologies for high quality and productivity in CHO expression systems. The following are fundamentally important for effective production. 1) Construction of cultivation process. The CHO-based cultivation process is well established and is a general platform of therapeutic antibody production. The cost of therapeutic protein production using CHO cells is equivalent to that using microbial culture. 2) Cell line development. Recent developments in omics technologies have been essential for the development of rational methods of constructing a cell line. 3) Cell engineering for post-translational steps. Improvement of secretion, folding and glycosylaiton is an important key issue for mammalian cell production systems. This review provides an overview of the industrial production of therapeutic proteins using a CHO cell expression system.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) CHO Cells (日) (読) [継承]
3. (英) Cell Culture Techniques (日) (読) [継承]
4. (英) Cricetinae (日) (読) [継承]
5. (英) Cricetulus (日) (読) [継承]
6. (英) Protein Engineering (日) (読) [継承]
7. (英) Protein Folding (日) (読) [継承]
8. (英) Recombinant Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Current Pharmaceutical Biotechnology (Bentham Science Publishers)
(pISSN: 1389-2010, eISSN: 1873-4316)

ISSN (任意): 1873-4316
ISSN: 1389-2010 (pISSN: 1389-2010, eISSN: 1873-4316)
Title: Current pharmaceutical biotechnology
Title(ISO): Curr Pharm Biotechnol
Publisher: Bentham Science Publishers
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 11 [継承]
(必須): 3 [継承]
(必須): 232 240 [継承]
都市 (任意):
年月日 (必須): 西暦 2010年 4月 初日 (平成 22年 4月 初日) [継承]
URL (任意):
DOI (任意): 10.2174/138920110791111960    (→Scopusで検索) [継承]
PMID (任意): 20210750    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000277124700002 [継承]
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Biotechnology, Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, Osaka 565-0871, Japan. omasa@bio.eng.osaka-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
5.(英) NumberOfReferences: 54  (日)    [継承]

標準的な表示

和文冊子 ● Takeshi Omasa, Masayoshi Onitsuka and Wook-Dong Kim : Cell engineering and cultivation of Chinese hamster ovary (CHO) cells, Current Pharmaceutical Biotechnology, Vol.11, No.3, 232-240, April 2010.
欧文冊子 ● Takeshi Omasa, Masayoshi Onitsuka and Wook-Dong Kim : Cell engineering and cultivation of Chinese hamster ovary (CHO) cells, Current Pharmaceutical Biotechnology, Vol.11, No.3, 232-240, April 2010.

関連情報

Number of session users = 0, LA = 0.80, Max(EID) = 374116, Max(EOID) = 1001822.