『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.工学部.化学応用工学科.物質合成化学講座 [継承]
2.物質変換化学 (2006年4月1日〜2016年3月31日) [継承]
著者 (必須): 1. (英) Berber, Reda Mohamed (日) モハメド レダ バーバー (読) もはめど れだ ばーばー
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2. (英) Hafez, Hazzaa Inas (日) イナス ハザー ハフェズ (読) いなす はざー はふぇず
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3.南川 慶二 ([徳島大学.教養教育院])
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4.森 健
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5.田中 正己 ([徳島文理大学])
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題名 (必須): (英) Nanocomposite Formulation System of Lipid Regulating Drugs Based on Layered Double Hydroxide: Synthesis, Characterization and Drug Release Properties  (日)    [継承]
副題 (任意):
要約 (任意): (英) To design a nanocomposite formulation system of lipid-regulating drugs with versatile approaches using layered double hydroxide (LDH) material. The co-precipitation technique has been used to prepare the selected drugs [bezafibrate (BZF) and clofibric acid (CF)]-LDH nanocomposites. The nanocomposite materials (BZF-LDH and CF-LDH) were characterized by X-ray powder diffraction, infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy. The in vitro study was investigated in simulated gastrointestinal solutions at 36.8°C. X-ray measurement and spectroscopic analysis indicated the formation of fully monophase drug-nanocomposites. The nanocomposites' gallery heights were calculated to be 23.5 and 16.3 Å for BZF and CF, respectively. The new gallery heights indicated that BZF and CF drugs have been stacked into LDH as a monolayer with a staggered inter-digitated arrangement. The size of the nanocomposites described by SEM microscopy was ∼ 0.1 μm. The nanocomposite formulation has improved the drugs properties (thermal stability, dissolution, and controlled release) beside the achievement of drug target delivery. Nanocomposites composed of lipid-regulating drugs (BZF and CF) with LDH were successfully synthesized as a new formulation system of this drug category. The LDH nanocomposite formulation system has improved the drugs release properties.  (日)    [継承]
キーワード (推奨): 1. (英) Hypolipidemic Agents (日) (読) [継承]
2. (英) Microscopy, Electron, Scanning (日) (読) [継承]
3. (英) Nanocomposites (日) (読) [継承]
4. (英) Spectrophotometry, Infrared (日) (読) [継承]
5. (英) Thermogravimetry (日) (読) [継承]
6. (英) X-Ray Diffraction (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Pharmaceutical Research (American Association of Pharmaceutical Scientists)
(pISSN: 0724-8741, eISSN: 1573-904X)

ISSN (任意): 1573-904X
ISSN: 0724-8741 (pISSN: 0724-8741, eISSN: 1573-904X)
Title: Pharmaceutical research
Title(ISO): Pharm. Res.
Supplier: Kluwer Online
Publisher: Springer US
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 27 [継承]
(必須): 114 [継承]
(必須): 2394 2401 [継承]
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年月日 (必須): 西暦 2010年 5月 29日 (平成 22年 5月 29日) [継承]
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DOI (任意): 10.1007/s11095-010-0175-x    (→Scopusで検索) [継承]
PMID (任意): 20512405    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Institute of Technology and Science, The University of Tokushima, Tokushima, 770-8506, Japan. mrberber@sy34.chem.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Mohamed Reda Berber, Inas Hazzaa Hafez, Keiji Minagawa, Takeshi Mori and Masami Tanaka : Nanocomposite Formulation System of Lipid Regulating Drugs Based on Layered Double Hydroxide: Synthesis, Characterization and Drug Release Properties, Pharmaceutical Research, Vol.27, No.114, 2394-2401, 2010.
欧文冊子 ● Mohamed Reda Berber, Inas Hazzaa Hafez, Keiji Minagawa, Takeshi Mori and Masami Tanaka : Nanocomposite Formulation System of Lipid Regulating Drugs Based on Layered Double Hydroxide: Synthesis, Characterization and Drug Release Properties, Pharmaceutical Research, Vol.27, No.114, 2394-2401, 2010.

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