『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域]) [継承]
著者 (必須): 1.Wang Siye
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学籍番号 (推奨):
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2. (英) Trong Quang Le (日) (読)
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3.千田 淳司 ([徳島大学.先端酵素学研究所.基幹研究部門])
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4.Cisse Youssouf ([徳島大学.疾患酵素学研究センター])
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5.矢野 仁康
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6.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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学籍番号 (推奨):
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題名 (必須): (英) Meckanisms of matrix metallo protease-9 wuregulation and tissue desfruction in rarious organs in influenza A virus infection  (日)    [継承]
副題 (任意):
要約 (任意): (英) Severe influenza is characterized clinicopathologically by multiple organ failure, although the relationship amongst virus and host factors that influence this morbid outcome and the underlying mechanisms of action remain unclear. The present study identified marked upregulation of matrix metalloproteinase (MMP)-9 and pro-inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) in various organs after intranasal infection of influenza A WSN virus. MMP-9 and TNF-alpha were upregulated in the lung, the site of initial infection, as well as in the brain and heart. The infection-induced MMP-9 upregulation was inhibited by anti-TNF-alpha antibodies and by anti-oxidative reagents pyrrolidine dithiocarbamate and N-acetyl-L-cysteine, which inhibit activation of nuclear factor kappa B (NF-kappaB), as well as by nordihydroguaiaretic acid, which inhibits activation of activator protein 1 (AP-1). In addition, MMP-9 upregulation via TNF-alpha was also suppressed by inhibitors of mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase 1/2 and p38, and partly by a c-Jun N-terminal kinase inhibitor. These results indicated that the influenza-induced MMP-9 upregulation in various organs is mediated through MAPK-NF-kappaB- and/or AP-1-dependent mechanisms. Strategies that neutralize TNF-alpha as well as inhibitors of MAPK-NF-kappa B- and/or AP-1-dependent pathways may be useful for suppressing the MMP-9 effect and thus preventing multiple organ failure in severe influenza.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Influenza A virus (日) (読) [継承]
3. (英) Lung (日) (読) [継承]
4. (英) MAP Kinase Signaling System (日) (読) [継承]
5. (英) Matrix Metalloproteinase 9 (日) (読) [継承]
6. (英) Mice (日) (読) [継承]
7. (英) Mice, Inbred C57BL (日) (読) [継承]
8. (英) NF-kappa B (日) (読) [継承]
9. (英) Orthomyxoviridae Infections (日) (読) [継承]
10. (英) Phosphorylation (日) (読) [継承]
11. (英) Transcription Factor AP-1 (日) (読) [継承]
12. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 57 [継承]
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(必須): 26 34 [継承]
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年月日 (必須): 西暦 2010年 2月 初日 (平成 22年 2月 初日) [継承]
URL (任意):
DOI (任意): 10.2152/jmi.57.26    (→Scopusで検索) [継承]
PMID (任意): 20299740    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Enzyme Chemistry, Institute for Enzyme Research, University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Siye Wang, Le Quang Trong, Junji Chida, Youssouf Cisse, Mihiro Yano and Hiroshi Kido : Meckanisms of matrix metallo protease-9 wuregulation and tissue desfruction in rarious organs in influenza A virus infection, The Journal of Medical Investigation : JMI, Vol.57, No.1,2, 26-34, 2010.
欧文冊子 ● Siye Wang, Le Quang Trong, Junji Chida, Youssouf Cisse, Mihiro Yano and Hiroshi Kido : Meckanisms of matrix metallo protease-9 wuregulation and tissue desfruction in rarious organs in influenza A virus infection, The Journal of Medical Investigation : JMI, Vol.57, No.1,2, 26-34, 2010.

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