『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Ozaki Shinya (日) (読)
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2.樋田 一徳
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3. (英) Suzuki Motohiko (日) (読)
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4. (英) Nakamura Yoshihisa (日) (読)
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5. (英) Ohno Nobuaki (日) (読)
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6. (英) Ohashi Taku (日) (読)
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7. (英) Nakayama Meiho (日) (読)
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8. (英) Hamajima Yuki (日) (読)
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9. (英) Inagaki Akira (日) (読)
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10.北岡 和義 ([徳島大学.教養教育院])
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11.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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12. (英) Murakami Shingo (日) (読)
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題名 (必須): (英) Impaired olfactory function in mice with allergic rhinitis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) OBJECTIVE: It has been reported that olfactory function is impaired in patients with allergic rhinitis. However, the mechanism of olfactory dysfunction in allergic rhinitis remains poorly understood. Because of difficulties in obtaining and analyzing human olfactory mucosa due to both technical and ethical issues, an animal model needs to be established to clarify the mechanism of olfactory dysfunction in allergic rhinitis. The purpose of this study was to study olfactory function and changes in olfactory mucosa using allergic rhinitis mice. METHODS: A model of allergic rhinitis mice with olfactory dysfunction was developed by sensitizing with ovalbumin (OVA), and intranasally challenging with the same allergen. Olfactory function of mice with or without allergic rhinitis was assessed by odor detection ability test with cycloheximide and local field potential (LFP) with 1-octanal. We also evaluated histological changes in the olfactory mucosa of allergic rhinitis mice by both light and electron microscopy. RESULTS: Both of odor detection ability test and LFP showed that olfactory function was impaired in mice with allergic rhinitis, but not in mice without allergic rhinitis. Histopathological findings showed prominent infiltration of eosinophils, plasma cells, neutrophils, mast cells, and macrophages in lamina propria of olfactory mucosa of mice with allergic rhinitis, although infiltration of these cells was not seen in control mice. Allergic rhinitis also increased the number and size of glands in olfactory mucosa, suggesting an elevated amount of mucin in olfactory mucosa. CONCLUSION: This study showed for the first time that mice with allergic rhinitis have impaired olfactory function, increased size and number of olfactory glands, and infiltration of eosinophils, neutrophils, mast cells, plasma cells, and macrophages in the olfactory mucosa. This suggests that allergic reactions are seen in olfactory mucosa of mice with allergic rhinitis, and that greater olfactory gland activity is associated with olfactory dysfunction. Also, this mouse model could provide an expedient system for analyzing mechanisms of olfactory dysfunction.  (日)    [継承]
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誌名 (必須): Auris, Nasus, Larynx (Society for Promotion of International Otorhinolaryngology)
(pISSN: 0385-8146, eISSN: 1879-1476)

ISSN (任意): 1879-1476
ISSN: 0385-8146 (pISSN: 0385-8146, eISSN: 1879-1476)
Title: Auris, nasus, larynx
Title(ISO): Auris Nasus Larynx
Publisher: Elsevier BV
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2010年 3月 24日 (平成 22年 3月 24日) [継承]
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DOI (任意): 10.1016/j.anl.2009.12.004    (→Scopusで検索) [継承]
PMID (任意): 20346605    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medical Science, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8602, Japan.  (日)    [継承]
2.(英) PublicationType: JOURNAL ARTICLE  (日)    [継承]

標準的な表示

和文冊子 ● Shinya Ozaki, Kazunori Toida, Motohiko Suzuki, Yoshihisa Nakamura, Nobuaki Ohno, Taku Ohashi, Meiho Nakayama, Yuki Hamajima, Akira Inagaki, Kazuyoshi Kitaoka, Hiroyoshi Sei and Shingo Murakami : Impaired olfactory function in mice with allergic rhinitis., Auris, Nasus, Larynx, Vol.37, No.5, 575-583, 2010.
欧文冊子 ● Shinya Ozaki, Kazunori Toida, Motohiko Suzuki, Yoshihisa Nakamura, Nobuaki Ohno, Taku Ohashi, Meiho Nakayama, Yuki Hamajima, Akira Inagaki, Kazuyoshi Kitaoka, Hiroyoshi Sei and Shingo Murakami : Impaired olfactory function in mice with allergic rhinitis., Auris, Nasus, Larynx, Vol.37, No.5, 575-583, 2010.

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