『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=207378)

EID=207378EID:207378, Map:0, LastModified:2014年2月28日(金) 13:53:35, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[吉丸 哲郎], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Suzuki Yoshihiro (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
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2.吉丸 哲郎 ([徳島大学.先端酵素学研究所.重点研究部門])
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Matsui Takashi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Ra Chisei (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Silver activates calcium signals in rat basophilic leukemia-2H3 mast cells by a mechanism that differs from the Fc epsilon RI-activated response.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We previously showed that silver stimulates degranulation and leukotriene (LT) C(4) production in rat basophilic leukemia mast cells and now show that silver induces these events by a mechanism that differs from the FcepsilonRI-mediated response. In common with FcepsilonRI cross-linking, silver induced tyrosine phosphorylation of extracellular signal-regulated kinases and furthermore, PD98059, a specific inhibitor of extracellular signal-regulated kinase kinase dose-dependently inhibited the silver-induced LTC(4) production. In contrast to FcepsilonRI cross-linking, silver had no effect on the production of IL-4 and TNF-alpha, indicating that different mechanisms are involved in the activation by these two stimuli. In line with this, silver had no or only marginal effect on the tyrosine phosphorylation of FcepsilonRIbeta, Lyn, Syk, and linker for activation of T cells, the early and crucial events in FcepsilonRI signaling. Silver induced calcium signals that were involved in the metal-induced degranulation, but not LTC(4) production. Unlike Ag, the silver-induced calcium signals were resistant to the depletion of thapsigargin-sensitive calcium stores and the inhibition of tyrosine kinases and phospholipase Cgamma. These findings indicate that silver activates mast cells by bypassing the early signaling events required for the induction of calcium influx. Our data strongly suggest the existence of an alternative pathway bypassing the early signaling events in mast cell activation and indicate that silver may be useful for analyses of such alternative mechanisms.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Calcium (日) (読) [継承]
3. (英) Calcium Signaling (日) (読) [継承]
4. (英) Carrier Proteins (日) (読) [継承]
5. (英) Cell Degranulation (日) (読) [継承]
6. (英) Enzyme Precursors (日) (読) [継承]
7. (英) Immunity, Innate (日) (読) [継承]
8. (英) Interleukin-4 (日) (読) [継承]
9. (英) Intracellular Signaling Peptides and Proteins (日) (読) [継承]
10. (英) Isoenzymes (日) (読) [継承]
11. (英) Leukemia, Basophilic, Acute (日) (読) [継承]
12. (英) Leukotriene C4 (日) (読) [継承]
13. (英) Mast Cells (日) (読) [継承]
14. (英) Mitogen-Activated Protein Kinases (日) (読) [継承]
15. (英) Phospholipase C gamma (日) (読) [継承]
16. (英) Phosphoproteins (日) (読) [継承]
17. (英) Protein-Tyrosine Kinases (日) (読) [継承]
18. (英) Rats (日) (読) [継承]
19. (英) Receptors, IgE (日) (読) [継承]
20. (英) Silver (日) (読) [継承]
21. (英) Silver Nitrate (日) (読) [継承]
22. (英) Thapsigargin (日) (読) [継承]
23. (英) Tumor Cells, Cultured (日) (読) [継承]
24. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
25. (英) Type C Phospholipases (日) (読) [継承]
26. (英) Tyrosine (日) (読) [継承]
27. (英) src-Family Kinases (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 169 [継承]
(必須): 7 [継承]
(必須): 3954 3962 [継承]
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年月日 (必須): 西暦 2002年 10月 1日 (平成 14年 10月 1日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 12244196    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000178288800062 [継承]
Scopus (任意):
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備考 (任意): 1.(英) Affiliation: Department of Immunology and Microbiology, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan. ysuzuki@med.nihon-u.ac.jp  (日)    [継承]
2.(英) PublicationType: Comparative Study  (日)    [継承]
3.(英) PublicationType: Journal Article  (日)    [継承]
4.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yoshihiro Suzuki, Tetsuro Yoshimaru, Takashi Matsui and Chisei Ra : Silver activates calcium signals in rat basophilic leukemia-2H3 mast cells by a mechanism that differs from the Fc epsilon RI-activated response., The Journal of Immunology, Vol.169, No.7, 3954-3962, 2002.
欧文冊子 ● Yoshihiro Suzuki, Tetsuro Yoshimaru, Takashi Matsui and Chisei Ra : Silver activates calcium signals in rat basophilic leukemia-2H3 mast cells by a mechanism that differs from the Fc epsilon RI-activated response., The Journal of Immunology, Vol.169, No.7, 3954-3962, 2002.

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