『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=207363EID:207363, Map:0, LastModified:2014年2月1日(土) 19:51:56, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[吉丸 哲郎], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Nakata Kazuko (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2.吉丸 哲郎 ([徳島大学.先端酵素学研究所.重点研究部門])
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学籍番号 (推奨):
[継承]
3. (英) Suzuki Yoshihiro (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Inoue Toshio (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Ra Chisei (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Yakura Hidetaka (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Mizuno Kazuya (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Src homology region 2 domain-containing phosphatase 1 (SHP-1), a cytoplasmic protein tyrosine phosphatase, plays an important role for the regulation of signaling from various hematopoietic cell receptors. Although SHP-1 is shown to be a negative signal modulator in mast cells, its precise molecular mechanisms are not well defined. To elucidate how SHP-1 regulates mast cell signaling, we established bone marrow-derived mast cells from SHP-1-deficient motheaten and wild-type mice and analyzed downstream signals induced by cross-linking of high affinity IgE receptor, Fc epsilonRI. Upon Fc epsilonRI ligation, motheaten-derived bone marrow-derived mast cells showed enhanced tyrosine phosphorylation of Src homology region 2 domain-containing leukocyte protein of 76 kDa (SLP-76) and linker for activation of T cells, activation of mitogen-activated protein kinases and gene transcription and production of cytokine. Because the activity of Syk, responsible for the phosphorylation of SLP-76 and linker for activation of T cells, is comparable irrespective of SHP-1, both molecules might be substrates of SHP-1 in mast cells. Interestingly, the absence of SHP-1 expression disrupted the association between SLP-76 and phospholipase Cgamma, which resulted in the decreased phospholipase Cgamma phosphorylation, calcium mobilization, and degranulation. Collectively, these results suggest that SHP-1 regulates Fc epsilonRI-induced downstream signaling events both negatively and positively by functioning as a protein tyrosine phosphatase and as an adaptor protein contributing to the formation of signaling complex, respectively.  (日)    [継承]
キーワード (推奨): 1. (英) Adaptor Proteins, Signal Transducing (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Calcium (日) (読) [継承]
4. (英) Cell Degranulation (日) (読) [継承]
5. (英) Extracellular Signal-Regulated MAP Kinases (日) (読) [継承]
6. (英) Gene Expression Regulation, Enzymologic (日) (読) [継承]
7. (英) Intracellular Signaling Peptides and Proteins (日) (読) [継承]
8. (英) Lymphocyte Activation (日) (読) [継承]
9. (英) Mast Cells (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Mice, Mutant Strains (日) (読) [継承]
12. (英) Phospholipase C gamma (日) (読) [継承]
13. (英) Phosphoproteins (日) (読) [継承]
14. (英) Phosphorylation (日) (読) [継承]
15. (英) Protein Tyrosine Phosphatase, Non-Receptor Type 6 (日) (読) [継承]
16. (英) Protein-Tyrosine Kinases (日) (読) [継承]
17. (英) Receptors, IgE (日) (読) [継承]
18. (英) Signal Transduction (日) (読) [継承]
19. (英) T-Lymphocytes (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 181 [継承]
(必須): 8 [継承]
(必須): 5414 5424 [継承]
都市 (任意):
年月日 (必須): 西暦 2008年 10月 15日 (平成 20年 10月 15日) [継承]
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DOI (任意):
PMID (任意): 18832698    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000260025300033 [継承]
Scopus (任意): 2-s2.0-54049146268 [継承]
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備考 (任意): 1.(英) Affiliation: Department of Immunology and Signal Transduction, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Science, Fuchu, Tokyo, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kazuko Nakata, Tetsuro Yoshimaru, Yoshihiro Suzuki, Toshio Inoue, Chisei Ra, Hidetaka Yakura and Kazuya Mizuno : Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1., The Journal of Immunology, Vol.181, No.8, 5414-5424, 2008.
欧文冊子 ● Kazuko Nakata, Tetsuro Yoshimaru, Yoshihiro Suzuki, Toshio Inoue, Chisei Ra, Hidetaka Yakura and Kazuya Mizuno : Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1., The Journal of Immunology, Vol.181, No.8, 5414-5424, 2008.

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