『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=206592EID:206592, Map:0, LastModified:2012年8月28日(火) 20:49:21, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[北岡 和義], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.北岡 和義 ([徳島大学.教養教育院])
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2.佐野 敦子
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3.近久 幸子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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4.吉﨑 和男
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5.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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題名 (必須): (英) Disturbance of rapid eye movement sleep in senescence-accelerated mouse prone/8 mice is improved by retinoic acid receptor agonist Am80 (Tamibarotene).  (日)    [継承]
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要約 (任意): (英) Senescence-accelerated mouse prone/8 (SAMP8) mice are known to exhibit age-related deterioration in sleep-wake architecture compared with senescence-accelerated mouse resistant/1 (SAMR1) mice. We investigated whether treatment with Am80 (Tamibarotene), a retinoic acid receptor agonist, would improve sleep in 9-10-month-old SAMP8 mice. One week of Am80 administration improved the decrease in rapid eye movement (REM) sleep shown by SAMP8 mice. Real-time RT-PCR analysis demonstrated an impairment in the hippocampal retinoid cascade (retinoic acid receptor alpha and transthyretin) in SAMP8 in comparison to SAMR1 mice. Am80 treatment induced an increase in mRNA expression in the vesicular acetylcholine transporter in the brainstem and transthyretin in the hippocampus. Furthermore, decreased cortical acetylcholine content in SAMP8 was improved by Am80 administration. Decreased non-REM sleep and delta oscillation were also observed in SAMP8 mice; however, this was not improved by Am80 administration. These results partially support the hypothesis that the effects of aging on sleep-wake architecture are improved by the activation of retinoic acid receptors. The improvement may be induced by the activation of the cholinergic pathway.  (日)    [継承]
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誌名 (必須): Neuroscience ([International Brain Research Organization])
(pISSN: 0306-4522, eISSN: 1873-7544)

ISSN (任意): 1873-7544
ISSN: 0306-4522 (pISSN: 0306-4522, eISSN: 1873-7544)
Title: Neuroscience
Title(ISO): Neuroscience
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2010年 2月 4日 (平成 22年 2月 4日) [継承]
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DOI (任意): 10.1016/j.neuroscience.2010.01.059    (→Scopusで検索) [継承]
PMID (任意): 20138974    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Affiliation: Department of Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) PublicationType: JOURNAL ARTICLE  (日)    [継承]

標準的な表示

和文冊子 ● Kazuyoshi Kitaoka, Atsuko Sano, Sachiko Chikahisa, Kazuo Yoshizaki and Hiroyoshi Sei : Disturbance of rapid eye movement sleep in senescence-accelerated mouse prone/8 mice is improved by retinoic acid receptor agonist Am80 (Tamibarotene)., Neuroscience, Vol.167, No.3, 573-582, 2010.
欧文冊子 ● Kazuyoshi Kitaoka, Atsuko Sano, Sachiko Chikahisa, Kazuo Yoshizaki and Hiroyoshi Sei : Disturbance of rapid eye movement sleep in senescence-accelerated mouse prone/8 mice is improved by retinoic acid receptor agonist Am80 (Tamibarotene)., Neuroscience, Vol.167, No.3, 573-582, 2010.

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