『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=205802EID:205802, Map:0, LastModified:2013年7月19日(金) 18:36:39, Operator:[細川 義隆], Avail:TRUE, Censor:0, Owner:[細川 義隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学])
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[継承]
2.細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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[継承]
3.尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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[継承]
4.湯本 浩通 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
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学籍番号 (推奨):
[継承]
5.中江 英明
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[継承]
6.松尾 敬志
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Proinflammatroy effects of muramyldipeptide on human gingival fibroblasts  (日)    [継承]
副題 (任意):
要約 (任意): (英) Because human gingival fibroblasts (HGFs) are the predominant cells in periodontal tissues, we hypothesized that HGFs are contributed to receptors for components of bacteria. In this study, we focused on expression and function of nucleotide binding oligomerization domain 2 (NOD2) in HGFs, which is a mammalian cytosolic pathogen recognition molecule. Expression of NOD2 in HGFs was examined by reverse transcriptase-polymerase chain reaction (RT-PCR) and flow cytometry. Production of interleukin (IL)-6, IL-8, cc chemokine ligand2, cxc chemokine ligand10 (CXCL10) and CXCL11 from HGFs was examined by enzyme-linked immunosorbent assay (ELISA). We used RT-PCR and immunohistochemistry to detect the NOD2 expression in human gingival tissues. We found clear NOD2 expression in HGFs. Upon stimulation with NOD2 agonist, muramyldipeptide (MDP), production of proinflammatory cytokines was enhanced. Moreover, MDP-induced production of proinflammatory cytokines was inhibited in a different manner by mitogen-activated protein kinase inhibitors and phosphatidylinositol 3-kinase inhibitor. Furthermore, MDP enhanced CXCL10 and CXCL11 productions by tumor necrosis factor-alpha (TNF-alpha)- or interferon-gamma (IFN-gamma)-stimulated HGFs, although MDP alone did not induce these chemokines. TNF-alpha and IFN-gamma increased NOD2 expression in HGFs. In addition, we detected NOD2 expression in mononuclear cells and HGFs in periodontally diseased tissues. These findings indicate that MDP which induces production of cytokines and chemokines from HGFs is related to the pathogenesis of periodontal disease.  (日)    [継承]
キーワード (推奨): 1. (英) Acetylmuramyl-Alanyl-Isoglutamine (日) (読) [継承]
2. (英) Adult (日) (読) [継承]
3. (英) Anthracenes (日) (読) [継承]
4. (英) Calcium-Calmodulin-Dependent Protein Kinases (日) (読) [継承]
5. (英) Cells, Cultured (日) (読) [継承]
6. (英) Chemokine CCL2 (日) (読) [継承]
7. (英) Chemokine CXCL10 (日) (読) [継承]
8. (英) Chemokine CXCL11 (日) (読) [継承]
9. (英) Chromones (日) (読) [継承]
10. (英) Chronic Periodontitis (日) (読) [継承]
11. (英) Enzyme Inhibitors (日) (読) [継承]
12. (英) Female (日) (読) [継承]
13. (英) Fibroblasts (日) (読) [継承]
14. (英) Flavonoids (日) (読) [継承]
15. (英) Gingiva (日) (読) [継承]
16. (英) Humans (日) (読) [継承]
17. (英) Imidazoles (日) (読) [継承]
18. (英) Inflammation Mediators (日) (読) [継承]
19. (英) Interferon-gamma (日) (読) [継承]
20. (英) Interleukin-6 (日) (読) [継承]
21. (英) Interleukin-8 (日) (読) [継承]
22. (英) JNK Mitogen-Activated Protein Kinases (日) (読) [継承]
23. (英) Male (日) (読) [継承]
24. (英) Middle Aged (日) (読) [継承]
25. (英) Morpholines (日) (読) [継承]
26. (英) Nod2 Signaling Adaptor Protein (日) (読) [継承]
27. (英) Periodontal Attachment Loss (日) (読) [継承]
28. (英) Periodontal Pocket (日) (読) [継承]
29. (英) Phosphatidylinositol 3-Kinases (日) (読) [継承]
30. (英) Pyridines (日) (読) [継承]
31. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Periodontal Research ([Blackwell Publishing Ltd])
(pISSN: 0022-3484, eISSN: 1600-0765)

ISSN (任意): 1600-0765
ISSN: 0022-3484 (pISSN: 0022-3484, eISSN: 1600-0765)
Title: Journal of periodontal research
Title(ISO): J Periodontal Res
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 45 [継承]
(必須): 2 [継承]
(必須): 193 199 [継承]
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年月日 (必須): 西暦 2010年 4月 初日 (平成 22年 4月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1600-0765.2009.01217.x    (→Scopusで検索) [継承]
PMID (任意): 20470259    (→Scopusで検索) [継承]
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WOS (任意): 000274809900006 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan. hosokawa@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Ikuko Hosokawa, Yoshitaka Hosokawa, Kazumi Ozaki, Hiromichi Yumoto, Hideaki Nakae and Takashi Matsuo : Proinflammatroy effects of muramyldipeptide on human gingival fibroblasts, Journal of Periodontal Research, Vol.45, No.2, 193-199, 2010.
欧文冊子 ● Ikuko Hosokawa, Yoshitaka Hosokawa, Kazumi Ozaki, Hiromichi Yumoto, Hideaki Nakae and Takashi Matsuo : Proinflammatroy effects of muramyldipeptide on human gingival fibroblasts, Journal of Periodontal Research, Vol.45, No.2, 193-199, 2010.

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