『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=204895EID:204895, Map:0, LastModified:2012年9月24日(月) 20:48:40, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[田中 栄二], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.顎口腔再建医学講座.口腔顎顔面矯正学 (2004年4月1日〜2015年3月31日) [継承]
2.広島大学 [継承]
著者 (必須): 1. (英) Kamiya Takashi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.谷本 幸太郎 ([広島大学])
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Tanne Yuki (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Lin YY (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Kunimatsu Ryo (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Yoshioka Motoko (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Tanaka Nobuaki (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8.田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9.丹根 一夫 ([広島大学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes  (日)    [継承]
副題 (任意):
要約 (任意): (英) Superficial zone protein (SZP) has been demonstrated to contribute to the boundary lubrication in synovial joints. This study was designed to clarify the modulation of SZP expression by mechanical stress in articular chondrocytes. Cyclic tensile strains of 7 and 21% cell elongation were applied to cultured chondrocytes obtained from porcine mandibular condylar cartilage. The mRNA levels of SZP, IL-1 beta, and TGF-beta1 were examined by a quantitative real-time PCR analysis. Protein level of SZP was examined by Western blotting. The SZP mRNA level was significantly upregulated after 12, 24, and 48 h by 7% elongation. Although SZP mRNA level was upregulated by 21% elongation after 12 h, it decreased to a lower level than the control after 48 h. The TGF-beta1 mRNA level exhibited an almost similar change to SZP. The IL-1 beta mRNA level was not changed markedly by 7% elongation. However, the IL-1 beta mRNA level was significantly increased by a 12-h application of 21% elongation. Western blot analysis revealed that the SZP expression was increased by 7% elongation, but decreased remarkably by 21% elongation. It is suggested from these findings that the SZP expression level in the chondrocytes is enhanced by optimal mechanical stimuli, but inhibited by excessive loading partly affected by TGF-beta1 and IL-1 beta, leading to the deterioration of joint lubrication. (c) 2009 Wiley Periodicals, Inc.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Blotting, Western (日) (読) [継承]
3. (英) Cells, Cultured (日) (読) [継承]
4. (英) Chondrocytes (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Glycoproteins (日) (読) [継承]
7. (英) Interleukin-1beta (日) (読) [継承]
8. (英) Physical Stimulation (日) (読) [継承]
9. (英) RNA, Messenger (日) (読) [継承]
10. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
11. (英) Swine (日) (読) [継承]
12. (英) Temporomandibular Joint (日) (読) [継承]
13. (英) Tensile Strength (日) (読) [継承]
14. (英) Transforming Growth Factor beta (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Biomedical Materials Research. Part A ([John Wiley & Sons, Inc.])
(pISSN: 1549-3296, eISSN: 1552-4965)

ISSN (任意): 1552-4965
ISSN: 1549-3296 (pISSN: 1549-3296, eISSN: 1552-4965)
Title: Journal of biomedical materials research. Part A
Title(ISO): J Biomed Mater Res A
Supplier: Society for Biomaterials
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 92 [継承]
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(必須): 801 805 [継承]
都市 (任意):
年月日 (必須): 西暦 2010年 2月 末日 (平成 22年 2月 末日) [継承]
URL (任意):
DOI (任意): 10.1002/jbm.a.32295    (→Scopusで検索) [継承]
PMID (任意): 19280634    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. tkotaro@hiroshima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Takashi Kamiya, Kotaro Tanimoto, Yuki Tanne, YY Lin, Ryo Kunimatsu, Motoko Yoshioka, Nobuaki Tanaka, Eiji Tanaka and Kazuo Tanne : Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes, Journal of Biomedical Materials Research. Part A, Vol.92, No.2, 801-805, 2010.
欧文冊子 ● Takashi Kamiya, Kotaro Tanimoto, Yuki Tanne, YY Lin, Ryo Kunimatsu, Motoko Yoshioka, Nobuaki Tanaka, Eiji Tanaka and Kazuo Tanne : Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes, Journal of Biomedical Materials Research. Part A, Vol.92, No.2, 801-805, 2010.

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