『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=204848)

EID=204848EID:204848, Map:0, LastModified:2012年9月22日(土) 18:46:42, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[長宗 秀明], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ソシオテクノサイエンス研究部.ライフシステム部門.生命システム工学 (2006年4月1日〜2016年3月31日) [継承]
著者 (必須): 1. (英) Haruta Ikuko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kikuchi Ken (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Hashimoto Etsuko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Nakamura Minoru (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Miyakawa Hiroshi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.弘田 克彦
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Shibata Noriyuki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Kato Hidehito (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Arimura Yutaka (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
10. (英) Kato Yoichiro (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
11. (英) Uchiyama Takehiko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
12.長宗 秀明 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
13. (英) Kobayashi Makio (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
14.三宅 洋一郎
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
15. (英) Shiratori Keiko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
16. (英) Yagi Junji (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Bacterial infection has become a focus of attention in the pathogenesis of primary biliary cirrhosis (PBC). We earlier reported that the bacterial lipoteichoic acid was detected at the sites of inflammation around damaged bile ducts in the livers of PBC, and PBC patients' sera showed high titers against streptococcal histone-like protein. Here, we investigated whether chronic bacterial exposure could trigger PBC-like epithelial cell damage in normal mouse. BALB/c mice were repeatedly inoculated with various bacteria for 8 weeks. At 1 week (Group 1) and 3, 4, or 20 months (long term; Group 2) after the final inoculation, mice were killed to obtain samples. In the livers of the Streptococcus intermedius (S.i.)-inoculated mice in Group 1, cellular infiltration was predominantly observed around the bile ducts over the hepatic parenchyma. In the S.i.-inoculated mice in Group 2, portal but not parenchymal inflammation was observed in the livers, and periductal cellular infiltrates were detected in the salivary glands. Both S.i.-inoculated Groups 1 and 2 BALB/c mice sera had antibodies against HuCCT1 biliary epithelial cells, anti-nuclear antibodies, and anti-gp210 antibodies, but not anti-mitochondrial antibodies. Immunoreactivity to histone-like DNA-binding protein of S.i. (S.i.-HLP) was detectable around the sites of chronic nonsuppurative destructive cholangitis in the portal area in the livers of both S.i.-inoculated Groups 1 and 2 BALB/c mice. Furthermore, anti-S.i.-HLP antibody bound to synthetic gp210 peptide, as well. Bacteria triggered PBC-like cholangitis, multifocal epithelial inflammation, and autoantibody production. Bacteria are likely involved in the pathogenesis of PBC and of associated multifocal epithelial inflammation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antibodies, Antinuclear (日) (読) [継承]
3. (英) Disease Models, Animal (日) (読) [継承]
4. (英) Epithelial Cells (日) (読) [継承]
5. (英) Immunity, Innate (日) (読) [継承]
6. (英) Inflammation (日) (読) [継承]
7. (英) Liver Cirrhosis, Biliary (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Mice, Inbred BALB C (日) (読) [継承]
10. (英) Nuclear Pore Complex Proteins (日) (読) [継承]
11. (英) Streptococcus intermedius (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Laboratory Investigation; a Journal of Technical Methods and Pathology (United States and Canadian Academy of Pathology)
(pISSN: 0023-6837, eISSN: 1530-0307)

ISSN (任意): 1530-0307
ISSN: 0023-6837 (pISSN: 0023-6837, eISSN: 1530-0307)
Title: Laboratory investigation; a journal of technical methods and pathology
Title(ISO): Lab Invest
Publisher: Springer Nature
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 90 [継承]
(必須): 4 [継承]
(必須): 577 588 [継承]
都市 (任意):
年月日 (必須): 西暦 2010年 2月 8日 (平成 22年 2月 8日) [継承]
URL (任意):
DOI (任意): 10.1038/labinvest.2010.40    (→Scopusで検索) [継承]
PMID (任意): 20142809    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) E-publish  (日)    [継承]

標準的な表示

和文冊子 ● Ikuko Haruta, Ken Kikuchi, Etsuko Hashimoto, Minoru Nakamura, Hiroshi Miyakawa, Katsuhiko Hirota, Noriyuki Shibata, Hidehito Kato, Yutaka Arimura, Yoichiro Kato, Takehiko Uchiyama, Hideaki Nagamune, Makio Kobayashi, Yoichiro Miyake, Keiko Shiratori and Junji Yagi : Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation., Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.90, No.4, 577-588, 2010.
欧文冊子 ● Ikuko Haruta, Ken Kikuchi, Etsuko Hashimoto, Minoru Nakamura, Hiroshi Miyakawa, Katsuhiko Hirota, Noriyuki Shibata, Hidehito Kato, Yutaka Arimura, Yoichiro Kato, Takehiko Uchiyama, Hideaki Nagamune, Makio Kobayashi, Yoichiro Miyake, Keiko Shiratori and Junji Yagi : Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation., Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.90, No.4, 577-588, 2010.

関連情報

Number of session users = 0, LA = 0.61, Max(EID) = 382798, Max(EOID) = 1022439.