『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=204663EID:204663, Map:0, LastModified:2012年10月18日(木) 11:43:34, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[湯本 浩通], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.高橋 加奈子
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[継承]
2.中西 正 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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[継承]
3.湯本 浩通 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
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学籍番号 (推奨):
[継承]
4. (英) Adachi Tomohiko (日) (読)
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[継承]
5.松尾 敬志
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[継承]
題名 (必須): (英) CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and pro-inflammatory cytokines  (日)    [継承]
副題 (任意):
要約 (任意): (英) Pulpitis is characterized by the marked infiltration of inflammatory cells in response to an invasion of caries-related bacteria. It is well known that chemokines regulate the trafficking of lymphocytes, and CC chemokine ligand 20 (CCL20) has been recently shown to play a crucial role in the recruitment of memory T cells and immature dendritic cells into inflammatory lesions. We previously reported that CCL20 was mainly expressed in microvascular endothelial cells and macrophages that accumulated in inflamed pulp tissues and that its specific receptor, CCR6, was expressed on infiltrated lymphocytes. However, the mechanism of CCL20 expression remains unclear. In this study, we investigated the expression of CCL20 in monocytes/macrophages, endothelial cells, and pulpal fibroblasts after stimulation with Streptococcus mutans, a representative of caries-related bacteria, or proinflammatory cytokines. CCL20 messenger RNA was detected by reverse transcription-polymerase chain reaction in inflamed pulp, but not in clinically normal pulp. By enzyme-linked immunosorbent assay, S. mutans induced a human monocytic cell line, differentiated macrophage-like THP-1 cells, and human umbilical vein endothelial cells (HUVEC) to produce an increased amount of CCL20. Lipoteichoic acid from S. mutans also elicited CCL20 production by HUVEC. Moreover, CCL20 production from pulpal fibroblasts was increased by stimulation with inetrleukin-1beta and tumor necrosis factor-alpha. Our results indicate that CCL20 expression is induced by stimulation with caries-related bacteria that have invaded deeply into the dentinal tubules as well as by proinflammatory cytokines in the inflamed pulpal lesions. It may be involved in the progression of pulpitis via accumulation of inflammatory cells.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) Cell Differentiation (日) (読) [継承]
4. (英) Cell Line (日) (読) [継承]
5. (英) Cells, Cultured (日) (読) [継承]
6. (英) Chemokine CCL20 (日) (読) [継承]
7. (英) Cytokines (日) (読) [継承]
8. (英) Dental Pulp (日) (読) [継承]
9. (英) Endothelial Cells (日) (読) [継承]
10. (英) Endothelium, Vascular (日) (読) [継承]
11. (英) Female (日) (読) [継承]
12. (英) Fibroblasts (日) (読) [継承]
13. (英) Humans (日) (読) [継承]
14. (英) Inflammation Mediators (日) (読) [継承]
15. (英) Intercellular Adhesion Molecule-1 (日) (読) [継承]
16. (英) Interleukin-1beta (日) (読) [継承]
17. (英) Interleukin-8 (日) (読) [継承]
18. (英) Lipopolysaccharides (日) (読) [継承]
19. (英) Macrophages (日) (読) [継承]
20. (英) Male (日) (読) [継承]
21. (英) Middle Aged (日) (読) [継承]
22. (英) Monocytes (日) (読) [継承]
23. (英) Pulpitis (日) (読) [継承]
24. (英) Streptococcus mutans (日) (読) [継承]
25. (英) Teichoic Acids (日) (読) [継承]
26. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
27. (英) Vascular Cell Adhesion Molecule-1 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Oral Microbiology and Immunology ([John Wiley & Sons, Inc.])
(pISSN: 0902-0055, eISSN: 1399-302X)

ISSN (任意): 1399-302X
ISSN: 0902-0055 (pISSN: 0902-0055, eISSN: 1399-302X)
Title: Oral microbiology and immunology
Title(ISO): Oral Microbiol. Immunol.
Publisher: Blackwell
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 320 327 [継承]
都市 (任意):
年月日 (必須): 西暦 2008年 8月 初日 (平成 20年 8月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1399-302X.2008.00431.x    (→Scopusで検索) [継承]
PMID (任意): 18582332    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan. tadashi@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kanako Takahashi, Tadashi Nakanishi, Hiromichi Yumoto, Tomohiko Adachi and Takashi Matsuo : CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and pro-inflammatory cytokines, Oral Microbiology and Immunology, Vol.23, No.4, 320-327, 2008.
欧文冊子 ● Kanako Takahashi, Tadashi Nakanishi, Hiromichi Yumoto, Tomohiko Adachi and Takashi Matsuo : CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and pro-inflammatory cytokines, Oral Microbiology and Immunology, Vol.23, No.4, 320-327, 2008.

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