『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=202682EID:202682, Map:0, LastModified:2017年8月28日(月) 19:29:19, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[佐藤 陽一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Sakamoto Kozue (日) (読)
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2.佐藤 陽一 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品情報学])
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3.勢井 雅子
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4.エヴィス アシュラフ
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5.中堀 豊
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題名 (必須): (英) Proteasome activity correlates with male BMI and contributes to the differentiation of adipocyte in hADSC  (日)    [継承]
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要約 (任意): (英) We have previously reported that 26S proteasome subunit mRNA expressions correlate with male body mass index (BMI). In this study, to investigate whether proteasome activities are correlated with BMI, we recruited 61 healthy young Japanese male subjects, measured proteasome activities in their plasma, and correlated them with their BMI and various metabolic factors. We found that among three different proteasome activities, chymotrypsin-like activity in plasma was positively correlated with BMI in healthy Japanese male subjects. Furthermore, we analyzed proteasome activity in vitro during the differentiation of human adipose-derived stem cell (hADSC) into mature adipocytes. In the early stage of differentiation, proteasome activity was at its highest level, and proteasome inhibitor could inhibit hADSC adipocyte differentiation. Our findings suggest that proteasome is an important controlling factor for the development of obesity and adipogenesis.  (日)    [継承]
キーワード (推奨): 1. (英) Adipocytes (日) (読) [継承]
2. (英) Adipogenesis (日) (読) [継承]
3. (英) Adult (日) (読) [継承]
4. (英) Asian Continental Ancestry Group (日) (読) [継承]
5. (英) Body Mass Index (日) (読) [継承]
6. (英) Cell Differentiation (日) (読) [継承]
7. (英) Cell Survival (日) (読) [継承]
8. (英) Cells, Cultured (日) (読) [継承]
9. (英) Cysteine Proteinase Inhibitors (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Leupeptins (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Obesity (日) (読) [継承]
14. (英) Proteasome Endopeptidase Complex (日) (読) [継承]
15. (英) Stem Cells (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrine ([Springer])
(pISSN: 1355-008X, eISSN: 1559-0100)

ISSN (任意): 1559-0100
ISSN: 1355-008X (pISSN: 1355-008X, eISSN: 1559-0100)
Title: Endocrine
Title(ISO): Endocrine
Supplier: Springer Online Journal Archive
Publisher: Springer New York
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 37 [継承]
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(必須): 274 279 [継承]
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年月日 (必須): 西暦 2010年 1月 5日 (平成 22年 1月 5日) [継承]
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DOI (任意): 10.1007/s12020-009-9298-4    (→Scopusで検索) [継承]
PMID (任意): 20960262    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kozue Sakamoto, Youichi Sato, Masako Sei, ASHRAF ABDEL AZIM EWIS and Yutaka Nakahori : Proteasome activity correlates with male BMI and contributes to the differentiation of adipocyte in hADSC, Endocrine, Vol.37, No.2, 274-279, 2010.
欧文冊子 ● Kozue Sakamoto, Youichi Sato, Masako Sei, ASHRAF ABDEL AZIM EWIS and Yutaka Nakahori : Proteasome activity correlates with male BMI and contributes to the differentiation of adipocyte in hADSC, Endocrine, Vol.37, No.2, 274-279, 2010.

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