『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=202346)

EID=202346EID:202346, Map:0, LastModified:2012年9月24日(月) 12:21:19, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[高浜 洋介], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Martin P. Andrea (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Marinkovic Tatjana (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Canasto-Chibuque Claudia (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Latif Rauf (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Unkeless C. Jay (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Davies F. Terry (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.高浜 洋介
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Furtado C. Glaucia (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Lira A. Sergio (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) CCR7 deficiency in NOD mice leads to thyroiditis and primary hypothyroidism  (日)    [継承]
副題 (任意):
要約 (任意): (英) CCR7 is involved in the initiation of immune responses and has been recently implicated in the control of tolerance. To analyze the role of CCR7 in autoimmunity, we backcrossed CCR7(ko/ko) mice (in which ko signifies deficient) onto the autoimmune-prone NOD background. Surprisingly, NODCCR7(ko/ko) mice never developed diabetes, but showed severe inflammation in multiple tissues including thyroid, lung, stomach, intestine, uterus, and testis. NODCCR7(ko/ko) mice had a marked enlargement of the thyroid gland (goiter) that was associated with circulating autoantibodies against thyroglobulin, and development of primary hypothyroidism (decreased levels of serum thyroxin, and augmented levels of thyroid-stimulating hormone in the pituitary gland), features found in Hashimoto's thyroiditis. Cells isolated from diseased thyroids and activated splenocytes from NODCCR7(ko/ko) animals induced goiter in NOD.SCID recipients, demonstrating that autoreactive cells were generated in the absence of CCR7. Moreover, thyroid disease could be accelerated in young NODCCR7(ko/ko) mice by immunization with thyroglobulin. These results demonstrate the complexity in the generation of multiple autoimmune phenotypes in NOD mice and indicate that CCR7 is a key molecule in their development.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cell Movement (日) (読) [継承]
3. (英) Crosses, Genetic (日) (読) [継承]
4. (英) Female (日) (読) [継承]
5. (英) Hypothyroidism (日) (読) [継承]
6. (英) Immunophenotyping (日) (読) [継承]
7. (英) Male (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Mice, Inbred C57BL (日) (読) [継承]
10. (英) Mice, Inbred NOD (日) (読) [継承]
11. (英) Mice, Knockout (日) (読) [継承]
12. (英) Mice, SCID (日) (読) [継承]
13. (英) Receptors, CCR7 (日) (読) [継承]
14. (英) Thyroiditis, Autoimmune (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 1550-6606
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 183 [継承]
(必須): 5 [継承]
(必須): 3073 3080 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 8月 12日 (平成 21年 8月 12日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.0900275    (→Scopusで検索) [継承]
PMID (任意): 19675158    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]

標準的な表示

和文冊子 ● Andrea P. Martin, Tatjana Marinkovic, Claudia Canasto-Chibuque, Rauf Latif, Jay C. Unkeless, Terry F. Davies, Yousuke Takahama, Glaucia C. Furtado and Sergio A. Lira : CCR7 deficiency in NOD mice leads to thyroiditis and primary hypothyroidism, The Journal of Immunology, Vol.183, No.5, 3073-3080, 2009.
欧文冊子 ● Andrea P. Martin, Tatjana Marinkovic, Claudia Canasto-Chibuque, Rauf Latif, Jay C. Unkeless, Terry F. Davies, Yousuke Takahama, Glaucia C. Furtado and Sergio A. Lira : CCR7 deficiency in NOD mice leads to thyroiditis and primary hypothyroidism, The Journal of Immunology, Vol.183, No.5, 3073-3080, 2009.

関連情報

Number of session users = 1, LA = 1.08, Max(EID) = 383267, Max(EOID) = 1024361.