『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Asakura, T. (日) (読)
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2. (英) Nakanishi, H. (日) (読)
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3. (英) Sakisaka, T. (日) (読)
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4. (英) Takahashi, K. (日) (読)
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5. (英) Mandai, K. (日) (読)
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6. (英) Nishimura, M. (日) (読)
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7.佐々木 卓也 ([徳島大学])
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8. (英) Takai, Y. (日) (読)
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題名 (必須): (英) Similar and differential behavior between the nectin-afadin-ponsin and cadherin-catenin systems during the formation and disruption of the polarized junctional alignment in epithelial cells.  (日)    [継承]
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要約 (任意): (英) We have recently identified a novel cell-cell adhesion system, named NAP system, which is localized at cadherin-based cell-cell adherens junctions (AJs). The NAP system is composed of at least nectin, afadin and ponsin. Nectin is an immunoglobulin-like cell adhesion molecule. Afadin is an actin filament-binding protein which associates nectin with the actin cytoskeleton. Ponsin is an afadin-binding protein which furthermore binds to vinculin and provides a possible linkage of nectin-afadin to cadherin-catenin through vinculin. We compared here the behaviour of the NAP and cadherin-catenin systems during the formation and disruption of the polarized junctional alignment in epithelial cells. At the early stage of the formation of the polarized junctional alignment in MTD-1 A cells, primordial spot-like junctions were formed at the tips of thin cellular protrusions radiating from adjacent cells. Nectin, afadin, ponsin, cadherin and catenin were simultaneously recruited to these junctions. As the cell polarization proceeded, the spot-like junctions were gradually fused to form belt-like AJs where all these proteins were concentrated. The disruption of cell-cell AJs in MDCK cells by culturing at a low Ca2+ concentration caused rapid endocytosis of cadherin, but not that of nectin or afadin. Addition of 12-O-tetradecanoylphorbol-13-acetate to the cells formed a tight junction-like structure where nectin and afadin, but not cadherin, accumulated. These results indicate that the NAP and cadherin-catenin systems show similar and differential behaviour during the formation and disruption of the polarized junctional alignment in epithelial cells.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cadherins (日) (読) [継承]
3. (英) Cell Adhesion (日) (読) [継承]
4. (英) Cell Adhesion Molecules (日) (読) [継承]
5. (英) Cell Line (日) (読) [継承]
6. (英) Epithelial Cells (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Immunoglobulins (日) (読) [継承]
9. (英) Intercellular Junctions (日) (読) [継承]
10. (英) Kinesin (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Microfilament Proteins (日) (読) [継承]
13. (英) Microscopy, Fluorescence (日) (読) [継承]
14. (英) Myosins (日) (読) [継承]
15. (英) Rabbits (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Genes to Cells ([日本分子生物学会])
(pISSN: 1356-9597, eISSN: 1365-2443)

ISSN (任意): 1356-9597
ISSN: 1356-9597 (pISSN: 1356-9597, eISSN: 1365-2443)
Title: Genes to cells : devoted to molecular & cellular mechanisms
Title(ISO): Genes Cells
Supplier: Molecular Biology Society of Japan
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 573 581 [継承]
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年月日 (必須): 西暦 1999年 10月 初日 (平成 11年 10月 初日) [継承]
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DOI (任意): 10.1046/j.1365-2443.1999.00283.x    (→Scopusで検索) [継承]
PMID (任意): 10583506    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita 565-0871, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● T. Asakura, H. Nakanishi, T. Sakisaka, K. Takahashi, K. Mandai, M. Nishimura, Takuya Sasaki and Y. Takai : Similar and differential behavior between the nectin-afadin-ponsin and cadherin-catenin systems during the formation and disruption of the polarized junctional alignment in epithelial cells., Genes to Cells, Vol.4, No.10, 573-581, 1999.
欧文冊子 ● T. Asakura, H. Nakanishi, T. Sakisaka, K. Takahashi, K. Mandai, M. Nishimura, Takuya Sasaki and Y. Takai : Similar and differential behavior between the nectin-afadin-ponsin and cadherin-catenin systems during the formation and disruption of the polarized junctional alignment in epithelial cells., Genes to Cells, Vol.4, No.10, 573-581, 1999.

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