『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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著者 (必須): 1.勝浦 桜子 ([徳島大学.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.社会環境衛生学講座.予防医学])
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2. (英) Imamura Tomomi (日) (読)
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3.板東 紀子
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4.山西 倫太郎
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題名 (必須): (英) beta-Carotene and beta-cryptoxanthin but not lutein evoke redox and immune changes in RAW264 murine macrophages.  (日)    [継承]
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要約 (任意): (英) The mechanism of immunological benefits induced by carotenoids has not been fully elucidated. Here, we investigated some of the immunity-related properties of beta-carotene and two other carotenoids, beta-cryptoxanthin, and lutein, on the murine macrophages cell line RAW264. beta-Carotene added to the culture medium accumulated in the cells in a time- and dose-dependent manner. The accumulation was positively correlated with cellular lipid peroxidation, demonstrating the pro-oxidative activity of beta-carotene, and also with the synthesis of glutathione, an intracellular antioxidant. Conversely, accumulation of beta-carotene was negatively correlated with the transcription of immune-active molecules, such as IL-1beta, IL-6, and IL-12 p40, in cells stimulated by LPS and INF-gamma. The transcription of the pro-inflammatory cytokines IL-1beta and IL-6 was more sensitive to the accumulation of beta-carotene than was IL-12 p40. The accumulation of beta-cryptoxanthin in cells resulted in effects similar to those of beta-carotene. However, lutein accumulated minimally and did not significantly affect the cells. These results demonstrate that beta-carotene, and beta-cryptoxanthin as well, can accumulate in RAW264 cells and induce changes in intracellular redox status, which in turn regulate the immune function of macrophages.  (日)    [継承]
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誌名 (必須): Molecular Nutrition & Food Research ([Wiley-VCH])
(pISSN: 1613-4125, eISSN: 1613-4133)

ISSN (任意): 1613-4133
ISSN: 1613-4125 (pISSN: 1613-4125, eISSN: 1613-4133)
Title: Molecular nutrition & food research
Title(ISO): Mol Nutr Food Res
Publisher: Wiley
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(必須): 11 [継承]
(必須): 1396 1405 [継承]
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年月日 (必須): 西暦 2009年 11月 初日 (平成 21年 11月 初日) [継承]
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DOI (任意): 10.1002/mnfr.200800566    (→Scopusで検索) [継承]
PMID (任意): 19760679    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Food Science, The University of Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Sakurako Katsuura, Tomomi Imamura, Noriko Bando and Rintaro Yamanishi : beta-Carotene and beta-cryptoxanthin but not lutein evoke redox and immune changes in RAW264 murine macrophages., Molecular Nutrition & Food Research, Vol.53, No.11, 1396-1405, 2009.
欧文冊子 ● Sakurako Katsuura, Tomomi Imamura, Noriko Bando and Rintaro Yamanishi : beta-Carotene and beta-cryptoxanthin but not lutein evoke redox and immune changes in RAW264 murine macrophages., Molecular Nutrition & Food Research, Vol.53, No.11, 1396-1405, 2009.

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