| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○著者 (必須): | 1. | 勝浦 桜子 ([徳島大学.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.社会環境衛生学講座.予防医学])
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| 2. | (英) Imamura Tomomi (日) (読)
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| 3. | 板東 紀子
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| 4. | 山西 倫太郎
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| ○題名 (必須): | □ | (英) beta-Carotene and beta-cryptoxanthin but not lutein evoke redox and immune changes in RAW264 murine macrophages. (日)
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| ○要約 (任意): | □ | (英) The mechanism of immunological benefits induced by carotenoids has not been fully elucidated. Here, we investigated some of the immunity-related properties of beta-carotene and two other carotenoids, beta-cryptoxanthin, and lutein, on the murine macrophages cell line RAW264. beta-Carotene added to the culture medium accumulated in the cells in a time- and dose-dependent manner. The accumulation was positively correlated with cellular lipid peroxidation, demonstrating the pro-oxidative activity of beta-carotene, and also with the synthesis of glutathione, an intracellular antioxidant. Conversely, accumulation of beta-carotene was negatively correlated with the transcription of immune-active molecules, such as IL-1beta, IL-6, and IL-12 p40, in cells stimulated by LPS and INF-gamma. The transcription of the pro-inflammatory cytokines IL-1beta and IL-6 was more sensitive to the accumulation of beta-carotene than was IL-12 p40. The accumulation of beta-cryptoxanthin in cells resulted in effects similar to those of beta-carotene. However, lutein accumulated minimally and did not significantly affect the cells. These results demonstrate that beta-carotene, and beta-cryptoxanthin as well, can accumulate in RAW264 cells and induce changes in intracellular redox status, which in turn regulate the immune function of macrophages. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Molecular Nutrition & Food Research ([Wiley-VCH])
(pISSN: 1613-4125, eISSN: 1613-4133)
| ○ISSN (任意): | □ | 1613-4133
ISSN: 1613-4125
(pISSN: 1613-4125, eISSN: 1613-4133) Title: Molecular nutrition & food researchTitle(ISO): Mol Nutr Food ResPublisher: Wiley (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 53
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| ○号 (必須): | □ | 11
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| ○頁 (必須): | □ | 1396 1405
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| ○年月日 (必須): | □ | 西暦 2009年 11月 初日 (平成 21年 11月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1002/mnfr.200800566 (→Scopusで検索)
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| ○PMID (任意): | □ | 19760679 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Food Science, The University of Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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