『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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組織 (推奨): 1.徳島大学.工学部.生物工学科.生物機能工学講座 [継承]
著者 (必須): 1. (英) Hata Takashi (日) 秦 隆志 (読) はた たかし
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2. (英) Sakamoto Takako (日) 坂本 貴子 (読) さかもと たかこ
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3.松木 均 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意): (英)   (日) 計画,考察   [継承]
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4.金品 昌志
役割 (任意): (英)   (日) 計画,解析,考察,論文執筆の指導   [継承]
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題名 (必須): (英) Partition coefficients of charged and uncharged local anesthetics into dipalmitoylphosphatidylcholine bilayer membrane: estimation from pH dependence on the depression of phase transition temperatures  (日)    [継承]
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要約 (任意): (英) Effects of the local anesthetics, dibucaine, bupivacaine and lidocaine on the phase transition temperatures of dipalmitoylphosphatidylcholine (DPPC) bilayer membrane were studied by the optical method. We focus our attention on pH dependence of the depression of main transition and pretransition temperatures. The temperatures of both transitions of DPPC bilayer membrane were depressed by the addition of anesthetics; the higher the value of pH, the larger the depression of main transition temperature and/or pretransition temperature by anesthetics. By extending the colligative thermodynamic framework to the depression of main transition temperature by an anesthetic, we can estimate the differential partition coefficient, which is defined by the difference in partition coefficients of an anesthetic into the ripple gel and liquid crystal phases. The difference in partition coefficient between the lamellar and ripple gel phases can also be estimated from the depression of pretransition temperature. Since the differential partition coefficients include both contributions of the charged and uncharged anesthetics, we could estimate the partition coefficients of the charged and uncharged anesthetic into the membranes from the pH dependence of differential partition coefficients. The liquid crystalline membrane of DPPC bilayer was more receptive to the uncharged local anesthetics than the charged species. The partition coefficients of the charged and uncharged anesthetics into the liquid crystalline phase of DPPC bilayer membrane were 3540 and 249000 (for dibucaine), 1120 and 83900 (for bupivacaine), 256 and 11700 (for lidocaine), respectively. The transfer free energy of uncharged anesthetics from the aqueous phase to the liquid crystalline membrane was well correlated to the local anesthetic potency.  (日) リン脂質ジパルミトイルホスファチジルコリン二分子膜の相転移温度におよぼす3種類の局所麻酔薬(ジブカイン,ブピバカイン,リドカイン)の影響を光学的手法で追跡した.脂質二分子膜の主転移および前転移温度は麻酔薬添加により降下し,pH増加につれて降下度は大きくなった.束一性の熱力学関係式より各局所麻酔薬の二相間分配係数を計算し,さらに分配係数のpH依存性から解離型および非解離型麻酔薬それぞれの分配係数を見積もった.脂質二分子膜は非解離型麻酔薬に強い感受性を示し,麻酔薬の取り込まれ易さは麻酔ポテンシーによく相関した.   [継承]
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発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): Colloids and Surfaces B:Biointerfaces ([Elsevier])
(pISSN: 0927-7765, eISSN: 1873-4367)

ISSN (任意): 1873-4367
ISSN: 0927-7765 (pISSN: 0927-7765, eISSN: 1873-4367)
Title: Colloids and surfaces. B, Biointerfaces
Title(ISO): Colloids Surf B Biointerfaces
Publisher: Elsevier BV
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年月日 (必須): 西暦 2001年 9月 1日 (平成 13年 9月 1日) [継承]
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DOI (任意): 10.1016/S0927-7765(01)00160-6    (→Scopusで検索) [継承]
PMID (任意): 11438243    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-0034959204 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Takashi Hata, Takako Sakamoto, Hitoshi Matsuki and Shoji Kaneshina : Partition coefficients of charged and uncharged local anesthetics into dipalmitoylphosphatidylcholine bilayer membrane: estimation from pH dependence on the depression of phase transition temperatures, Colloids and Surfaces B:Biointerfaces, Vol.22, No.1, 77-84, 2001.
欧文冊子 ● Takashi Hata, Takako Sakamoto, Hitoshi Matsuki and Shoji Kaneshina : Partition coefficients of charged and uncharged local anesthetics into dipalmitoylphosphatidylcholine bilayer membrane: estimation from pH dependence on the depression of phase transition temperatures, Colloids and Surfaces B:Biointerfaces, Vol.22, No.1, 77-84, 2001.

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