| ○種別 (必須): | □ | 総説·解説
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 川人 伸次 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
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| 2. | 北畑 洋
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| 3. | 大下 修造
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| ○題名 (必須): | □ | (英) Problems associated with glucose toxicity: Role of hyperglycemia-induced oxidative stress. (日)
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| ○要約 (任意): | □ | (英) Glucose homeostasis deficiency leads to a chronic increase in blood glucose concentration. In contrast to physiological glucose concentration, chronic superphysiological glucose concentration negatively affects a large number of organs and tissues. Glucose toxicity means a decrease in insulin secretion and an increase in insulin resistance due to chronic hyperglycemia. It is now generally accepted that glucose toxicity is involved in the worsening of diabetes by affecting the secretion of beta-cells. Several mechanisms have been proposed to explain the adverse effects of hyperglycemia. It was found that persistent hyperglycemia caused the functional decline of neutrophils. Infection is thus the main problem resulting from glucose toxicity in the acute phase. In other words, continued hyperglycemia is a life-threatening risk factor, not only in the chronic but also the acute phase, and it becomes a risk factor for infection, particularly in the perioperative period. (日)
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| ○キーワード (推奨): | 1. | (英) Diabetes Complications (日) (読)
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| 2. | グルコース (glucose)
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| 3. | 生体恒常性 (homeostasis/->キーワード[ホメオスタシス])
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| 4. | (英) Humans (日) (読)
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| 5. | (英) Hyperglycemia (日) (読)
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| 6. | インスリン (insulin)
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| 7. | インスリン抵抗性 (insulin resistance)
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| 8. | 酸化ストレス (oxidative stress)
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| 9. | (英) Surgical Wound Infection (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | World Journal of Gastroenterology : WJG (Baishideng Publishing)
(pISSN: 1007-9327, eISSN: 2219-2840)
| ○ISSN (任意): | □ | 1007-9327
ISSN: 1007-9327
(pISSN: 1007-9327, eISSN: 2219-2840) Title: World journal of gastroenterologyTitle(ISO): World J GastroenterolPublisher: Baishideng Publishing Group Inc (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 15
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| ○号 (必須): | □ | 33
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| ○頁 (必須): | □ | 4137 4142
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2009年 11月 7日 (平成 21年 11月 7日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3748/wjg.15.4137 (→Scopusで検索)
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| ○PMID (任意): | □ | 19725147 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Anesthesiology, Tokushima University Medical and Dental Hospital, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. kawahito@clin.med.tokushima-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Review (日)
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| 4. | (英) NumberOfReferences: 58 (日)
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| 5. | (英) OtherID: PMC2738809 (日)
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