| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 北畑 洋
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| ○学籍番号 (推奨): |
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| 2. | 野﨑 淳平
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| 3. | 川人 伸次 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
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| 4. | 富野 武人
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| 5. | 大下 修造
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| ○題名 (必須): | □ | (英) Low-dose sevoflurane inhalation enhances late cardioprotection from the anti-ulcer drug geranylgeranylacetone. (日)
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| ○要約 (任意): | □ | (英) We investigated in rabbits whether sevoflurane enhances late cardioprotection induced by geranylgeranylacetone (GGA), a gastric antiulcer drug. S(+)-ketamine and xylazine-anesthetized rabbits were assigned to one of seven experimental groups: a control (vehicle only) group, a GGA group, a sevoflurane group, a GGA+sevoflurane group, a sodium 5-hydroxydecanoate (5HD) group, a GGA + 5HD group, and a heat stress group. All rabbits were subjected to 30 min of coronary artery occlusion followed by 3 h of reperfusion. Rabbits were pretreated with IV vehicle, GGA (10 mg/kg), or heat stress (42 degrees C for 15 min) 24 h before coronary occlusion. Sevoflurane (0.5 minimum alveolar concentration) or 5HD (5 mg/kg) were administered before myocardial ischemia. Myocardial infarct size and the area at risk for ischemia were measured, and heat shock protein (Hsp) 70 levels in each experimental group were determined. Compared with vehicle only, GGA significantly reduced the size of myocardial infarction in relation to the area at risk (39 +/- 10% vs 59 +/- 9%, P < 0.02). Sevoflurane enhanced the GGA-induced cardioprotection (23 +/- 17%, P < 0.05 vs GGA). The cardioprotective effect of GGA was abolished by administration of 5HD (56 +/- 15%, P < 0.01). GGA enhanced Hsp 70 expression compared with that in the control group (0.69 +/- 0.15 vs 0.36 +/- 0.05, P < 0.02). Administration of GGA with sevoflurane resulted in the same level of Hsp 70 expression as GGA (0.69 +/- 0.16, P > 0.98). GGA appears to reduce myocardial infarct size in association with increased Hsp 70 expression. Sevoflurane enhances the GGA-induced cardioprotective effect. (日)
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| ○キーワード (推奨): | 1. | (英) Administration, Inhalation (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Anti-Ulcer Agents (日) (読)
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| 4. | (英) Cardiotonic Agents (日) (読)
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| 5. | (英) Coronary Vessels (日) (読)
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| 6. | (英) Diterpenes (日) (読)
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| 7. | (英) Drug Synergism (日) (読)
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| 8. | (英) HSP70 Heat-Shock Proteins (日) (読)
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| 9. | (英) Hemodynamics (日) (読)
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| 10. | (英) Male (日) (読)
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| 11. | (英) Methyl Ethers (日) (読)
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| 12. | (英) Myocardial Infarction (日) (読)
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| 13. | (英) Protein Kinase C (日) (読)
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| 14. | (英) Rabbits (日) (読)
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| 15. | (英) Time Factors (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Anesthesia & Analgesia (International Anesthesia Research Society(IARS))
(pISSN: 0003-2999, eISSN: 1526-7598)
| ○ISSN (任意): | □ | 1526-7598
ISSN: 0003-2999
(pISSN: 0003-2999, eISSN: 1526-7598) Title: Anesthesia and analgesiaTitle(ISO): Anesth AnalgPublisher: Lippincott Williams and Wilkins (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 107
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 755 761
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 9月 初日 (平成 20年 9月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1213/ane.0b013e31817f0e61 (→Scopusで検索)
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| ○PMID (任意): | □ | 18713879 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000258702500007
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Anesthesiology, The University of Tokushima Graduate School, Institute of Health Biosciences, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. hiroshi@clin.med.tokushima-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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