『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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学究種別 (推奨): 博士課程学生による研究報告 [継承]
組織 (推奨): 1.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域]) [継承]
著者 (必須): 1.小野 公嗣
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2.宍戸 裕二 ([徳島大学.先端酵素学研究所.次世代酵素学研究領域])
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3. (英) Park Ki Hwan (日) 朴 煥埼 (読) ぱく はんき
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4. (英) Kawazoe Tomoya (日) 川添 僚也 (読) かわぞえ ともや
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5. (英) Iwana Sanae (日) 岩名 沙奈恵 (読) いわな さなえ
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6.鄭 丞弼
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7. (英) El-Magd Mohamed Abou Rabab (日) (読)
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8.頼田 和子
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9. (英) Okano Mai (日) 岡野 舞 (読) おかの まい
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10. (英) Watanabe Takeshi (日) (読)
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11.佐野 暢哉
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12.坂東 良美 ([徳島大学.病院.中央診療施設等.病理部])
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13. (英) Arima Kunimasa (日) 有馬 邦正 (読) ありま くにまさ
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14.坂井 隆志
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15.福井 清 ([徳島大学])
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題名 (必須): (英) Potential pathophysiological role of D-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain  (日)    [継承]
副題 (任意):
要約 (任意): (英) D-Amino acid oxidase (DAO) is a peroxisomal flavoenzyme that catalyzes oxidative deamination of a wide range of D-amino acids. Among the possible substrates of DAO in vivo, D-serine is proposed to be a neuromodulator of the N-methyl-D-aspartate (NMDA) type glutamate receptor. The gene for DAO was reported to be associated with schizophrenia. Since DAO is expected to be one of the key enzymes in the regulation of NMDA neurotransmission, the modulation of the enzyme activity is expected to be therapeutical for neuronal disorders. In search of the pathophysiological role of DAO, we analyzed the distribution of DAO mRNA and protein in the rat and human brain. In rat, the distribution of DAO mRNA was newly detected in choroid plexus (CP) epithelial cells in addition to glial cells of pons, medulla oblongata, and especially Bergmann glia of cerebellum. Moreover, to investigate how DAO expression level is altered in schizophrenia, we performed immunohistochemistry in the human brain. In agreement with the results in the rat brain, the immunoreactivity for DAO was detected in glial cells of rhombencephalon and in CP. Furthermore, higher level of DAO expression was observed in schizophrenic CP epithelial cells than that in non-schizophrenic cases. These results suggest that an increase in DAO expression in parts of the brain is involved in aberrant D-amino acid metabolism. In particular, gene expression of DAO in CP suggests that DAO may regulate D-amino acid concentration by modulating the cerebrospinal fluid and may be regarded as a potential therapeutic target for schizophrenia.  (日)    [継承]
キーワード (推奨): 1.D-アミノ酸酸化酵素 (D-amino acid oxidase) [継承]
2.D-セリン代謝 (D-Serine metabolism) [継承]
3.遺伝子発現 (gene expression) [継承]
4.統合失調症 (schizophrenia) [継承]
5.脈絡叢 (choroid plexus) [継承]
6.グルタミン酸性神経伝達 (glutamatergic neurotransmission) [継承]
発行所 (推奨): Springer Wien New York [継承]
誌名 (必須): Journal of Neural Transmission ([European Society for Clinical Neuropharmacology])
(pISSN: 0300-9564, eISSN: 1435-1463)

ISSN (任意): 1435-1463
ISSN: 0300-9564 (pISSN: 0300-9564, eISSN: 1435-1463)
Title: Journal of neural transmission (Vienna, Austria : 1996)
Title(ISO): J Neural Transm (Vienna)
Supplier: Springer Online Journal Archive
Publisher: Springer Wien
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1335 1347 [継承]
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年月日 (必須): 西暦 2009年 9月 15日 (平成 21年 9月 15日) [継承]
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DOI (任意): 10.1007/s00702-009-0289-7    (→Scopusで検索) [継承]
PMID (任意): 19685198    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Enzyme Pathophysiology, The Institute for Enzyme Research, The University of Tokushima, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Koji Ono, Yuji Shishido, Hwan Ki Park, Tomoya Kawazoe, Sanae Iwana, Seongpil Chung, Rabab Mohamed Abou El-Magd, Kazuko YORITA, Mai Okano, Takeshi Watanabe, Nobuya Sano, Yoshimi Bando, Kunimasa Arima, Takashi Sakai and Kiyoshi Fukui : Potential pathophysiological role of D-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain, Journal of Neural Transmission, Vol.116, No.10, 1335-1347, 2009.
欧文冊子 ● Koji Ono, Yuji Shishido, Hwan Ki Park, Tomoya Kawazoe, Sanae Iwana, Seongpil Chung, Rabab Mohamed Abou El-Magd, Kazuko YORITA, Mai Okano, Takeshi Watanabe, Nobuya Sano, Yoshimi Bando, Kunimasa Arima, Takashi Sakai and Kiyoshi Fukui : Potential pathophysiological role of D-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain, Journal of Neural Transmission, Vol.116, No.10, 1335-1347, 2009.

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