『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=194029EID:194029, Map:0, LastModified:2012年10月4日(木) 20:43:02, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[安井 夏生], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kubo Takahiro (日) (読)
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2.松井 好人
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3. (英) Naka Norifumi (日) (読)
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[継承]
4. (英) Araki Nobuhito (日) (読)
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[継承]
5. (英) Goto Tomohiro (日) (読)
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6.油形 公則
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7.遠藤 健次
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8.安井 夏生
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9. (英) Myoui Akira (日) (読)
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10. (英) Kawabata Hidehiko (日) (読)
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11. (英) Yoshikawa Hideki (日) (読)
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12. (英) Ueda Takafumi (日) (読)
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題名 (必須): (英) Expression of HMGA2-LPP and LPP-HMGA2 Fusion Genes in Lipoma: Identification of a Novel Type of LPP-HMGA2 Transcript in Four Cases  (日)    [継承]
副題 (任意):
要約 (任意): (英) In a subset of lipoma, a specific t(3;12)(q27-28;q14-15) chromosomal translocation leads to the fusion of the high mobility group A2 (HMGA2) gene and the lipoma preferred partner (LPP) gene. Although the expression of HMGA2-LPP fusion gene has been reported in lipomas, the reciprocal LPP-HMGA2 fusion gene has rarely been described. Ninety-eight cases of lipoma were analyzed for the possible expression of HMGA2-LPP and LPP-HMGA2 fusion genes using a reverse-transcription polymerase chain reaction method. Ten lipomas (10%) revealed both HMGA2-LPP and LPP-HMGA2 fusion transcripts, nine (9%) only HMGA2-LPP, and three (3%) only LPP-HMGA2. DNA sequencing analysis demonstrated that the HMGA2-LPP transcript in 19 lipomas consisted of exons 1-3 of HMGA2 and exons 9-11 of LPP, which was described previously. Out of 13 lipomas with LPP-HMGA2 transcript, 9 were associated with a previously reported LPP-HMGA2 fusion transcript, which fuses exon 8 of LPP to exon 4 of HMGA2, while 4 with a novel type of LPP-HMGA2 fusion transcript, which fuses exon 7 of LPP to exon 4 of HMGA2. In addition to the HMGA2-LPP fusion gene, the LPP-HMGA2 fusion gene could have some specific roles for lipomagenesis. The biological implications of the expression and the variation of LPP-HMGA2 fusion transcripts need to be elucidated.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) Cytoskeletal Proteins (日) (読) [継承]
4. (英) Female (日) (読) [継承]
5. (英) HMGA2 Protein (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) LIM Domain Proteins (日) (読) [継承]
8. (英) Lipoma (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) Middle Aged (日) (読) [継承]
11. (英) RNA, Messenger (日) (読) [継承]
12. (英) Recombinant Fusion Proteins (日) (読) [継承]
13. (英) Retrospective Studies (日) (読) [継承]
14. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
15. (英) Transcription, Genetic (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Anticancer Research (International Institute of Anticancer Research(IIAR))
(pISSN: 0250-7005, eISSN: 1791-7530)

ISSN (任意): 0250-7005
ISSN: 0250-7005 (pISSN: 0250-7005, eISSN: 1791-7530)
Title: Anticancer research
Title(ISO): Anticancer Res
Publisher: International Institute of Anticancer Research
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 29 [継承]
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(必須): 2357 2360 [継承]
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年月日 (必須): 西暦 2009年 6月 初日 (平成 21年 6月 初日) [継承]
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PMID (任意): 19528502    (→Scopusで検索) [継承]
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WOS (任意): 000267389500063 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Orthopaedic Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takahiro Kubo, Yoshito Matsui, Norifumi Naka, Nobuhito Araki, Tomohiro Goto, Kiminori Yukata, Kenji Endo, Natsuo Yasui, Akira Myoui, Hidehiko Kawabata, Hideki Yoshikawa and Takafumi Ueda : Expression of HMGA2-LPP and LPP-HMGA2 Fusion Genes in Lipoma: Identification of a Novel Type of LPP-HMGA2 Transcript in Four Cases, Anticancer Research, Vol.29, No.6, 2357-2360, 2009.
欧文冊子 ● Takahiro Kubo, Yoshito Matsui, Norifumi Naka, Nobuhito Araki, Tomohiro Goto, Kiminori Yukata, Kenji Endo, Natsuo Yasui, Akira Myoui, Hidehiko Kawabata, Hideki Yoshikawa and Takafumi Ueda : Expression of HMGA2-LPP and LPP-HMGA2 Fusion Genes in Lipoma: Identification of a Novel Type of LPP-HMGA2 Transcript in Four Cases, Anticancer Research, Vol.29, No.6, 2357-2360, 2009.

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