『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=193840EID:193840, Map:0, LastModified:2012年9月19日(水) 12:09:10, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[安井 夏生], Read:継承, Write:継承, Delete:継承.
○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨):
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1. (英) Nishimoto Kazumasa (日) (読)
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○学籍番号 (推奨):
[継承]
2. (英) Kochi Yuta (日) (読)
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[継承]
3. (英) Ikari Katsunori (日) (読)
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○学籍番号 (推奨):
[継承]
4. (英) Yamamoto Kazuhiko (日) (読)
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[継承]
5. (英) Suzuki Akari (日) (読)
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6. (英) Shimane Kenichi (日) (読)
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[継承]
7. (英) Nakamura Yusuke (日) (読)
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8. (英) Yano Koichiro (日) (読)
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9. (英) Iikuni Noriko (日) (読)
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10. (英) Tsukahara So (日) (読)
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[継承]
11.鎌谷 直之 ([徳島大学.ゲノム機能研究センター])
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12. (英) Okamoto Hiroshi (日) (読)
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13. (英) Kaneko Hirotaka (日) (読)
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14. (英) Kawaguchi Yasushi (日) (読)
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15. (英) Hara Masako (日) (読)
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16. (英) Toyama Yoshiaki (日) (読)
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17. (英) Horiuchi Takahiko (日) (読)
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18. (英) Tao Kayoko (日) (読)
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19.安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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20.浜田 大輔 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.運動機能外科学]/[徳島大学.病院.診療科.感覚·皮膚·運動機能科.整形外科])
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21.安井 夏生
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22.井上 寛
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○学籍番号 (推奨):
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23.板倉 光夫
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24. (英) Yamanaka Hisashi (日) (読)
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○学籍番号 (推奨):
[継承]
25. (英) Momohara Shigeki (日) (読)
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○学籍番号 (推奨):
[継承]
○題名 (必須): □(英) Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) The primary aim of this study was to investigate the association of polymorphisms of TRAF1-C5, a newly identified rheumatoid arthritis (RA) risk locus in Caucasians, with susceptibility to RA and systemic lupus erythematosus (SLE) in Japanese populations. Gene expression levels of TRAF1 and C5 to assess the functional significance of genotypes were also analysed. A multicentre association study consisting of 4 RA case-control series (4397 cases and 2857 controls) and 3 SLE case-control series (591 cases and 2199 shared controls) was conducted. Genotyping was performed using TaqMan genotyping assay for two single nucleotide polymorphisms (SNPs) that showed the best evidence of association in the previous Caucasian studies. Quantifications of TRAF1 and C5 expression were performed with TaqMan expression assay. Significant differences in allele frequency for both SNPs were observed between RA and control subjects (combined odds ratio = 1.09), while no significant difference was detected between patients with SLE and controls. Interestingly, alleles rs3761847 A and rs10818488 G had increased the risk for RA in the present study, while they decreased the risk in the original studies. A significant difference was found between risk allele carriers and non-carriers of rs10818488 for the expression level of TRAF1 in phorbol myristate acetate-stimulated lymphoblastoid cell lines (p = 0.04). Association of TRAF1-C5 locus with RA susceptibility was detected in the Japanese populations with modest magnitude, while no significant association was observed for SLE. Significant positive effect of genotype on the expression of TRAF1 might support the genetic association between TRAF1 and RA.  (日)    [継承]
○キーワード (推奨): 1. (英) Arthritis, Rheumatoid (日) (読) [継承]
2. (英) Asian Continental Ancestry Group (日) (読) [継承]
3. (英) Autoantibodies (日) (読) [継承]
4. (英) Case-Control Studies (日) (読) [継承]
5. (英) Cell Line (日) (読) [継承]
6. (英) Complement C5 (日) (読) [継承]
7. (英) Female (日) (読) [継承]
8. (英) Genetic Predisposition to Disease (日) (読) [継承]
9. (英) Genome-Wide Association Study (日) (読) [継承]
10. (英) Genotype (日) (読) [継承]
11. (英) Hand Joints (日) (読) [継承]
12. (英) Humans (日) (読) [継承]
13. (英) Lupus Erythematosus, Systemic (日) (読) [継承]
14. (英) Male (日) (読) [継承]
15. (英) Middle Aged (日) (読) [継承]
16. (英) Polymorphism, Single Nucleotide (日) (読) [継承]
17. (英) TNF Receptor-Associated Factor 1 (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □Annals of the Rheumatic Diseases (Empire Rheumatism Council/British Medical Association)
(pISSN: 0003-4967, eISSN: 1468-2060)

○ISSN (任意): □1468-2060
ISSN: 0003-4967 (pISSN: 0003-4967, eISSN: 1468-2060)
Title: Annals of the rheumatic diseases
Title(ISO): Ann Rheum Dis
Publisher: BMJ Group
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □69 [継承]
○号 (必須): □2 [継承]
○頁 (必須): □368 373 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2009年 3月 30日 (平成 21年 3月 30日) [継承]
○URL (任意):
○DOI (任意): □10.1136/ard.2008.104315    (→Scopusで検索) [継承]
○PMID (任意): □19336421    (→Scopusで検索) [継承]
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○備考 (任意): 1.(英) Article.Affiliation: Institute of Rheumatology, Tokyo Women's Medical University, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Multicenter Study  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kazumasa Nishimoto, Yuta Kochi, Katsunori Ikari, Kazuhiko Yamamoto, Akari Suzuki, Kenichi Shimane, Yusuke Nakamura, Koichiro Yano, Noriko Iikuni, So Tsukahara, Naoyuki Kamatani, Hiroshi Okamoto, Hirotaka Kaneko, Yasushi Kawaguchi, Masako Hara, Yoshiaki Toyama, Takahiko Horiuchi, Kayoko Tao, Koji Yasutomo, Daisuke Hamada, Natsuo Yasui, Hiroshi Inoue, Mitsuo Itakura, Hisashi Yamanaka and Shigeki Momohara : Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese., Annals of the Rheumatic Diseases, Vol.69, No.2, 368-373, 2009.
欧文冊子 ● Kazumasa Nishimoto, Yuta Kochi, Katsunori Ikari, Kazuhiko Yamamoto, Akari Suzuki, Kenichi Shimane, Yusuke Nakamura, Koichiro Yano, Noriko Iikuni, So Tsukahara, Naoyuki Kamatani, Hiroshi Okamoto, Hirotaka Kaneko, Yasushi Kawaguchi, Masako Hara, Yoshiaki Toyama, Takahiko Horiuchi, Kayoko Tao, Koji Yasutomo, Daisuke Hamada, Natsuo Yasui, Hiroshi Inoue, Mitsuo Itakura, Hisashi Yamanaka and Shigeki Momohara : Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese., Annals of the Rheumatic Diseases, Vol.69, No.2, 368-373, 2009.

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