| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 生島 仁史 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.放射線科学系.放射線治療学])
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| 2. | 岩本 誠司
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| 3. | (英) Osaki Kyohsuke (日) (読)
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| 4. | (英) Furutani Shunsuke (日) (読)
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| 5. | (英) Yamashita Kyoh (日) (読)
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| 6. | 川中 崇 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学]/[徳島大学.病院.診療科.放射線科.放射線治療科])
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| 7. | 久保 亜貴子 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学]/[徳島大学.病院.診療科.放射線科])
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| 8. | 竹川 佳宏
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| 9. | 工藤 隆治 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔外科学]/[徳島大学.歯学部.歯学科.口腔疾患系臨床歯学講座.口腔外科学])
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| 10. | (英) Kanayama Hiroomi (日) (読)
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| 11. | 西谷 弘
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| ○題名 (必須): | □ | (英) Effective bladder preservation strategy with low-dose radiation therapy and concurrent intraarterial chemotherapy for muscle-invasive bladder cancer. (日)
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| ○要約 (任意): | □ | (英) PURPOSE: The aim of this study was to evaluate retrospectively the toxicity and response, bladder preservation, and survival of patients with muscle-invasive bladder cancer treated with multimodality therapy consisting of low-dose radiation therapy (RT) and concurrent intraarterial chemotherapy (IACT). METHODS AND MATERIALS:. Between November 1999 and July 2005, a total of 27 consecutive, previously untreated patients with muscle-invasive bladder cancer underwent transurethral bladder tumor resection followed by concurrent low-dose RT and IACT. Patients who achieved a complete response (CR) were followed up closely without further therapy, and patients who did not achieve a CR underwent further treatment. RESULTS: Complete response was achieved in 22 of 27 patients (81%). Of these 22 patients, 7 developed recurrences, and 3 died of their disease. In five patients who did not achieve CR, one died from bone metastases. The 3-year overall survival rate was 81%, with a median follow-up time of 27 months; and 22 of 27 patients (81%) with a preserved bladder were tumor-free at the last follow-up. Three patients (11%) developed grade 3 acute hematological toxicity. CONCLUSION: Multimodality therapy consisting of low-dose RT and concurrent IACT for muscle-invasive bladder cancer can achieve survival rates similar to those in patients treated with radical cystectomy, with successful bladder preservation and minimal adverse effects. (日)
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| ○キーワード (推奨): | 1. | (英) Antineoplastic Combined Chemotherapy Protocols (日) (読)
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| 2. | (英) Combined Modality Therapy (日) (読)
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| 3. | (英) Cystectomy (日) (読)
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| 4. | (英) Female (日) (読)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Infusions, Intra-Arterial (日) (読)
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| 7. | (英) Male (日) (読)
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| 8. | (英) Neoplasm Invasiveness (日) (読)
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| 9. | (英) Neoplasm Recurrence, Local (日) (読)
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| 10. | (英) Radiotherapy Dosage (日) (読)
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| 11. | (英) Retrospective Studies (日) (読)
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| 12. | (英) Survival Rate (日) (読)
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| 13. | (英) Treatment Outcome (日) (読)
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| 14. | (英) Urinary Bladder Neoplasms (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Radiation Medicine ([社団法人 日本医学放射線学会])
(pISSN: 0288-2043, eISSN: 1862-5274)
| ○ISSN (任意): | □ | 0288-2043
ISSN: 0288-2043
(pISSN: 0288-2043, eISSN: 1862-5274) Title: Radiation medicineTitle(ISO): Radiat MedPublisher: Springer Science+Business Media (NLM Catalog)
(医中誌Web)
(Scopus)
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(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 26
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 156 163
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 4月 初日 (平成 20年 4月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s11604-007-0211-x (→Scopusで検索)
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| ○PMID (任意): | □ | 18683571 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Radiology, University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. ikushima@clin.med.tokushima-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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