『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=193277)

EID=193277EID:193277, Map:0, LastModified:2012年10月18日(木) 22:57:04, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[勢井 宏義], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Oishi Katsutaka (日) (読)
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[継承]
2. (英) Ohkura Naoki (日) (読)
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3.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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[継承]
4. (英) Matsuda Juzo (日) (読)
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[継承]
5.石田 直理雄
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題名 (必須): (英) CLOCK regulates the circadian rhythm of kaolin-induced writhing behavior in mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Kaolin-induced writhing reaction is a simple and convenient model of bradykinin-induced pain for assessment of analgesic actions. In this study, we demonstrated that the number of kaolin-induced writhing reaction was fluctuated in a circadian manner that peaked at the end of the resting period (dusk) and reduced during the active (dark) period in mice. Circadian rhythm of the writhing intensity was completely phase-shifted by a time-imposed restricted feeding. On the other hand, 24 h of food deprivation did not affect the writhing intensity, suggesting that the endogenous clock that can be entrained to the scheduled feeding is responsible to the circadian intensity of the writhing reaction. Day/night fluctuation of the writhing intensity was completely abolished and the writhing reaction was significantly reduced in the circadian clock deficient Clock-mutant mice, although the kaolin-induced bradykinin production and blood pressure suppression were not affected in these mutant mice. Our present study suggested that the circadian variation of the pain sensitivity is governed by the food-entrainable endogenous clock and by the circadian clock molecules in mammals.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antidiarrheals (日) (読) [継承]
3. (英) Appetite Regulation (日) (読) [継承]
4. (英) Biological Clocks (日) (読) [継承]
5. (英) Blood Pressure (日) (読) [継承]
6. (英) Bradykinin (日) (読) [継承]
7. (英) Circadian Rhythm (日) (読) [継承]
8. (英) Food Deprivation (日) (読) [継承]
9. (英) Hypothalamus (日) (読) [継承]
10. (英) Kaolin (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Mice, Inbred BALB C (日) (読) [継承]
13. (英) Mice, Inbred C57BL (日) (読) [継承]
14. (英) Mice, Inbred ICR (日) (読) [継承]
15. (英) Mice, Neurologic Mutants (日) (読) [継承]
16. (英) Mutation (日) (読) [継承]
17. (英) Pain (日) (読) [継承]
18. (英) Pain Measurement (日) (読) [継承]
19. (英) Pain Threshold (日) (読) [継承]
20. (英) Trans-Activators (日) (読) [継承]
発行所 (推奨):
誌名 (必須): NeuroReport ([Lippincott Williams & Wilkins])
(pISSN: 0959-4965, eISSN: 1473-558X)

ISSN (任意): 0959-4965
ISSN: 0959-4965 (pISSN: 0959-4965, eISSN: 1473-558X)
Title: Neuroreport
Title(ISO): Neuroreport
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 18 [継承]
(必須): 18 [継承]
(必須): 1925 1928 [継承]
都市 (任意):
年月日 (必須): 西暦 2007年 12月 3日 (平成 19年 12月 3日) [継承]
URL (任意):
DOI (任意): 10.1097/WNR.0b013e3282f1ca00    (→Scopusで検索) [継承]
PMID (任意): 18007188    (→Scopusで検索) [継承]
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WOS (任意): 000251355300010 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Katsutaka Oishi, Naoki Ohkura, Hiroyoshi Sei, Juzo Matsuda and Norio Ishida : CLOCK regulates the circadian rhythm of kaolin-induced writhing behavior in mice., NeuroReport, Vol.18, No.18, 1925-1928, 2007.
欧文冊子 ● Katsutaka Oishi, Naoki Ohkura, Hiroyoshi Sei, Juzo Matsuda and Norio Ishida : CLOCK regulates the circadian rhythm of kaolin-induced writhing behavior in mice., NeuroReport, Vol.18, No.18, 1925-1928, 2007.

関連情報

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