『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=193269)

EID=193269EID:193269, Map:0, LastModified:2012年8月28日(火) 20:35:51, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[勢井 宏義], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
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組織 (推奨):
著者 (必須): 1.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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[継承]
2. (英) Oishi Katsutaka (日) (読)
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[継承]
3.近久 幸子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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[継承]
4.北岡 和義 ([徳島大学.教養教育院])
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[継承]
5.武田 英二
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[継承]
6.石田 直理雄
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[継承]
題名 (必須): (英) Diurnal amplitudes of arterial pressure and heart rate are dampened in Clock mutant mice and adrenalectomized mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Arterial pressure (AP), heart rate (HR), and cardiovascular diseases, including ischemic heart attack and cerebrovascular accident, show diurnal variation. Evidence that circadian-related genes contribute to cardiovascular control has been accumulated. In this study, we measured the AP and HR of Clock mutant mice on the Jcl/ICR background to determine the role of the Clock gene in cardiovascular function. Mice with mutated Clock genes had a dampened diurnal rhythm of AP and HR, compared with wild-type control mice, and this difference disappeared after adrenalectomy. The diurnal acrophase in both mean arterial pressure and HR was delayed significantly in Clock mutant mice, compared with wild-type mice, and this difference remained after adrenalectomy. Clock mutant mice had a lower concentration of plasma aldosterone, compared with wild-type mice. Our data suggest that the adrenal gland is involved in the diurnal amplitude, but not the acrophase, of AP and HR, and that the function of the Clock gene may be related to the nondipping type of AP elevation.  (日)    [継承]
キーワード (推奨): 1. (英) Adrenalectomy (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Blood Pressure (日) (読) [継承]
4. (英) Circadian Rhythm (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Genotype (日) (読) [継承]
7. (英) Heart Rate (日) (読) [継承]
8. (英) Male (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Inbred BALB C (日) (読) [継承]
11. (英) Mice, Inbred C57BL (日) (読) [継承]
12. (英) Mice, Inbred ICR (日) (読) [継承]
13. (英) Mice, Mutant Strains (日) (読) [継承]
14. (英) Mutation (日) (読) [継承]
15. (英) Trans-Activators (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 0013-7227
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 149 [継承]
(必須): 7 [継承]
(必須): 3576 3580 [継承]
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年月日 (必須): 西暦 2008年 4月 10日 (平成 20年 4月 10日) [継承]
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DOI (任意): 10.1210/en.2007-1714    (→Scopusで検索) [継承]
PMID (任意): 18403480    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Integrative Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. sei@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hiroyoshi Sei, Katsutaka Oishi, Sachiko Chikahisa, Kazuyoshi Kitaoka, Eiji Takeda and Norio Ishida : Diurnal amplitudes of arterial pressure and heart rate are dampened in Clock mutant mice and adrenalectomized mice., Endocrinology, Vol.149, No.7, 3576-3580, 2008.
欧文冊子 ● Hiroyoshi Sei, Katsutaka Oishi, Sachiko Chikahisa, Kazuyoshi Kitaoka, Eiji Takeda and Norio Ishida : Diurnal amplitudes of arterial pressure and heart rate are dampened in Clock mutant mice and adrenalectomized mice., Endocrinology, Vol.149, No.7, 3576-3580, 2008.

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