| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 酒井 徹 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.実践栄養学])
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| 2. | (英) Kogiso Mari (日) 小木曽 真理 (読)
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| ○題名 (必須): | □ | (英) Soy isoflavones and immunity. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The amount of soy products consumed in Japan is much greater than that in Western countries. Recent evidence indicates that soy isoflavones play a beneficial role in obesity, cancer, osteoporosis, and cardiovascular disease. The soybean isoflavone genistein is present at high levels in soy products. Genistein is structurally similar to 17beta-estradiol (E2), and genistein has been suggested to be act as E2 or an antagonist against E2. Genistein suppresses antigen-specific immune response in vivo and lymphocyte proliferation response in vitro. However, genistein enhances the cytotoxic response mediated by NK and cytotoxic T cells and the cytokine production from T cells. Thus, the effect of genistein on immunity is immune cell-dependent. Due to its unique effect on immune function, genistein has been used for the treatment of the diseases in animal models and it has been found that genistein inhibits allergic inflammatory responses. In this review, we summarize current studies related to the effect of isoflavone genistein on the immune system. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antibody Formation (日) (読)
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| 3. | (英) Cell Differentiation (日) (読)
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| 4. | (英) Genistein (日) (読)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Immunity (日) (読)
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| 7. | (英) Immunity, Cellular (日) (読)
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| 8. | (英) Isoflavones (日) (読)
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| 9. | (英) Neoplasms, Experimental (日) (読)
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| 10. | (英) Phytoestrogens (日) (読)
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| 11. | (英) Soybeans (日) (読)
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| 12. | (英) T-Lymphocytes (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1349-6867
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: Tokushima Daigaku Igakubu (NLM Catalog)
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| ○巻 (必須): | □ | 55
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| ○号 (必須): | □ | 3-4
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| ○頁 (必須): | □ | 167 173
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 8月 初日 (平成 20年 8月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.55.167 (→Scopusで検索)
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| ○PMID (任意): | □ | 18797128 (→Scopusで検索)
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| ○機関リポジトリ : | □ | 110856
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Public Health and Applied Nutrition, Institute of Health Bioscience, the University of Tokushima Graduate School, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Review (日)
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| 5. | (英) NumberOfReferences: 38 (日)
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