『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=193264EID:193264, Map:0, LastModified:2012年8月28日(火) 20:35:23, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[勢井 宏義], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ogawa Tokiko (日) (読)
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[継承]
2. (英) Shishioh-Ikejima Nobue (日) (読)
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[継承]
3. (英) Konishi Hiroyuki (日) (読)
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[継承]
4. (英) Makino Tetsuya (日) (読)
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[継承]
5.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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[継承]
6. (英) Kiryu-Seo Sumiko (日) (読)
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[継承]
7. (英) Tanaka Masaaki (日) (読)
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[継承]
8. (英) Watanabe Yasuyoshi (日) (読)
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9. (英) Kiyama Hiroshi (日) (読)
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題名 (必須): (英) Chronic stress elicits prolonged activation of alpha-MSH secretion and subsequent degeneration of melanotroph.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Prolonged stress affects homeostasis in various organs and induces stress-associated disorders. We examined the cellular changes of pituitary gland under the continuous stress condition using a rat model in which rats were kept in a cage filled with water to a height of 1.5 cm for up to 5 days. Among the pituitary hormone mRNAs, proopiomelanocortin mRNA was up-regulated specifically in the intermediate lobe (IL) of this rat model. Additionally, the peripheral blood levels of alpha-melanocyte stimulating hormone (alpha-MSH), a major product of proopiomelanocortin in IL were increased. The alpha-MSH secreting cells, melanotrophs, showed a markedly developed endoplasmic reticulum and Golgi apparatus in the early phase of the experiment. Subsequent continuous stress caused remarkable dilation of the endoplasmic reticulum, disruption of the Golgi structure, and the degeneration of some melanotrophs. In addition the dopaminergic nerve fibers from hypothalamus were markedly decreased in IL. A dopamine antagonist elicited the similar morphologic changes of melanotroph in normal rat. These findings suggest that prolonged stress suppressed hypothalamus-derived dopamine release in IL, which elicited over-secretion of alpha-MSH from the melanotrophs. The present study also suggests that prolonged hyperactivation of endocrine cells could lead to disorder of secretion mechanisms and eventual degeneration.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Conditioning, Classical (日) (読) [継承]
3. (英) Dopamine (日) (読) [継承]
4. (英) Dopamine Agents (日) (読) [継承]
5. (英) Endoplasmic Reticulum (日) (読) [継承]
6. (英) Golgi Apparatus (日) (読) [継承]
7. (英) Male (日) (読) [継承]
8. (英) Melanotrophs (日) (読) [継承]
9. (英) Nerve Degeneration (日) (読) [継承]
10. (英) Pro-Opiomelanocortin (日) (読) [継承]
11. (英) RNA, Messenger (日) (読) [継承]
12. (英) Radioimmunoassay (日) (読) [継承]
13. (英) Rats (日) (読) [継承]
14. (英) Rats, Sprague-Dawley (日) (読) [継承]
15. (英) Stress, Psychological (日) (読) [継承]
16. (英) Up-Regulation (日) (読) [継承]
17. (英) alpha-MSH (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Neurochemistry ([The International Society for Neurochemistry])
(pISSN: 0022-3042, eISSN: 1471-4159)

ISSN (任意): 1471-4159
ISSN: 0022-3042 (pISSN: 0022-3042, eISSN: 1471-4159)
Title: Journal of neurochemistry
Title(ISO): J. Neurochem.
Supplier: International Society for Neurochemistry
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 109 [継承]
(必須): 5 [継承]
(必須): 1389 1399 [継承]
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年月日 (必須): 西暦 2009年 3月 23日 (平成 21年 3月 23日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1471-4159.2009.06057.x    (→Scopusで検索) [継承]
PMID (任意): 19476550    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Anatomy & Neurobiology, Graduate School of Medicine, Osaka City University, Osaka, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tokiko Ogawa, Nobue Shishioh-Ikejima, Hiroyuki Konishi, Tetsuya Makino, Hiroyoshi Sei, Sumiko Kiryu-Seo, Masaaki Tanaka, Yasuyoshi Watanabe and Hiroshi Kiyama : Chronic stress elicits prolonged activation of alpha-MSH secretion and subsequent degeneration of melanotroph., Journal of Neurochemistry, Vol.109, No.5, 1389-1399, 2009.
欧文冊子 ● Tokiko Ogawa, Nobue Shishioh-Ikejima, Hiroyuki Konishi, Tetsuya Makino, Hiroyoshi Sei, Sumiko Kiryu-Seo, Masaaki Tanaka, Yasuyoshi Watanabe and Hiroshi Kiyama : Chronic stress elicits prolonged activation of alpha-MSH secretion and subsequent degeneration of melanotroph., Journal of Neurochemistry, Vol.109, No.5, 1389-1399, 2009.

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